Computational RNA Structure Prediction
Computational RNA Structure Prediction
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DOI：
10.2174/157489308783329823
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发表时间：
2008
影响因子：
4
通讯作者：
E. Capriotti;M. Martí-Renom
中科院分区：
文献类型：
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作者：
E. Capriotti;M. Martí-Renom
核糖酶是一类具有酶样功能的RNA分子，自发现核糖酶以来，RNA作为简单的信息传递分子的观点不断受到挑战。此外，最近发现的微小RNA分子，如RNA和小干扰RNA，正在改变我们对基因表达如何调控的看法。因此，现在已知RNA分子在细胞内携带大量的生物功能，包括信息传递，酶催化和细胞过程的调节。与蛋白质类似，功能性RNA分子折叠成其天然的三维（3D）构象，这对于发挥其生物活性至关重要。尽管在理解RNA的折叠和展开方面取得了进展，但我们对RNA分子采用其生物活性结构的原子机制的了解仍然有限。在这篇综述中，我们概述了控制RNA结构的一般原理，并描述了用于分析和预测RNA二级和三级结构的数据库和算法。最后，我们评估了RNA结构空间当前覆盖范围对RNA结构比较建模的影响。
The view of RNA as simple information transfer molecule has been continuously challenged since the discov- ery of ribozymes, a class of RNA molecules with enzyme-like function. Moreover, the recent discovery of tiny RNA molecules such asRNAs and small interfering RNA, is transforming our thinking about how gene expression is regu- lated. Thus, RNA molecules are now known to carry a large repertory of biological functions within cells including in- formation transfer, enzymatic catalysis and regulation of cellular processes. Similar to proteins, functional RNA mole- cules fold into their native three-dimensional (3D) conformation, which is essential for performing their biological activ- ity. Despite advances in understanding the folding and unfolding of RNA, our knowledge of the atomic mechanism by which RNA molecules adopt their biological active structure is still limited. In this review, we outline the general princi- ples that govern RNA structure and describe the databases and algorithms for analyzing and predicting RNA secondary and tertiary structure. Finally, we assess the impact of the current coverage of the RNA structural space on comparative modeling RNA structures.