β-Lactam Resistance Mechanisms of Methicillin-Resistant Staphylococcus aureus
β-Lactam Resistance Mechanisms of Methicillin-Resistant Staphylococcus aureus
复制标题
耐甲氧西林金黄色葡萄球菌的β-内酰胺耐药机制
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
P. Moreillon
中科院分区：
文献类型：
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作者：
M. Franciolli;J. Billé;M. Glauser;P. Moreillon
: In vitro and in vivo activity of amoxicillin and penicillin G alone or combined with a penicillinase inhibitor (clavulanate) were tested against five isogenic pairs of methicillin-resistant Staphylococcus aureus (MRSA) producing or not producing penicillinase. Loss of the penicillinase plasmid caused an eight times or greater reduction in the MICs of amoxicillin and penicillin G (from greater than or equal to 64 to 8 micrograms/ml), but not of the penicillinase-resistant drugs methicillin and cloxacillin (greater than or equal to 64 micrograms/ml). This difference in antibacterial effectiveness correlated with a more than 10 times greater penicillin-binding protein 2a affinity of amoxicillin and penicillin G than of methicillin and a greater than or equal to 90% successful amoxicillin treatment of experimental endocarditis due to penicillinase-negative MRSA compared with cloxacillin, which was totally ineffective (P less than .001). Amoxicillin was also effective against penicillinase-producing parent MRSA, provided it was combined with clavulanate. Penicillinase-sensitive beta-lactam antibiotics plus penicillinase inhibitors might offer a rational alternative treatment for MRSA infections.
