Microionization constants of sulphonamides.
Microionization constants of sulphonamides.
复制标题
磺胺类药物的微电离常数。
DOI：
10.1016/0039-9140(80)80061-0
复制
发表时间：
1980
期刊：
影响因子：
6.1
通讯作者：
T. Ishimitsu
中科院分区：
文献类型：
--
作者：
H. Sakurai;T. Ishimitsu
本文用电位滴定法和分光光度法分别测定了12种磺胺类药物在15°、25°和35°离子强度为0.1的NaClO_4水溶液中的宏观电离常数和热力学参数。微电离常数和互变异构常数（两性离子与不带电或中性物质的浓度比）根据Edsall方法结合互补三刺激比色法获得。利用微电离常数，计算了三种磺胺类药物的物种分布随pH的变化。
The macroionization constants and thermodynamic parameters of twelve commercial sulphonamides were determined by potentiometric titration at 15°, 25° and 35° and by spectrophotometry at 25°, in aqueous solution of ionic strength 0.1 (NaClO4). The microionization constants and the tautomeric constants (concentration ratios of zwitterion to uncharged or neutral species) were obtained according to the Edsall method combined with complementary tristimulus colorimetry. By utilizing the microionization constants, the species distribution as a function of pH were calculated for the three kinds of sulphonamides.