Response to hypercapnia and exercise hyperpnea in graded anesthesia.
Response to hypercapnia and exercise hyperpnea in graded anesthesia.
复制标题
分级麻醉中对高碳酸血症和运动呼吸过度的反应。
DOI：
10.1152/jappl.1984.57.6.1796
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
T. Takishima
中科院分区：
文献类型：
--
作者：
T. Chonan;Y. Kikuchi;W. Hida;C. Shindoh;H. Inoue;H. Sasaki;T. Takishima
我们研究了8只狗在分级麻醉下对高碳酸血症的反应和对运动的反应之间的关系。在三个等级的氯醛糖-氨基甲酸乙酯麻醉下，通过CO2再呼吸法测量对高碳酸血症的反应。在轻度（L）、中度（M）和深度（D）麻醉中，对高碳酸血症的反应程度（Δ VE/Δ PETCO 2，1 × min-1 × Torr-1）分别为0.40 +/- 0.05（平均值+/- SE）、0.24 +/- 0.03和0.10 +/- 0.02，彼此之间存在显著差异。在每种麻醉等级下，通过电刺激双侧股神经和坐骨神经4 min进行运动。运动开始后达到通气量增加（tauVE）完全反应63%的时间在L、M和D中分别为28.3 +/- 1.5、38.1 +/- 5.2和56.0 +/- 6.1 s。在稳态运动期间，L、M和D的每分钟通气量（VE）从静息值3.93 +/-0.34、2.97 +/- 0.17和1.69 +/-0.14 1 X min-1显著增加至6.17 +/-0.39、5.14 +/- 0.30和3.41 +/-0.16 1 X min-1，而呼气末CO2张力（PETCO 2）在L中从35.7 +/-0.9显著降低至34.8 +/- 0.9，在M中没有变化（从38.9 +/- 0.8为38.9 +/- 1.1），在D中从45.1 +/- 1.7 Torr显著增加至47.3 +/- 1.9。（250字处删节）
We examined the relationship between response to hypercapnia and ventilatory response to exercise under graded anesthesia in eight dogs. The response to hypercapnia was measured by the CO2 rebreathing method under three grades of chloralose-urethan anesthesia. The degrees of response to hypercapnia (delta VE/delta PETCO2, 1 X min-1 X Torr-1) in light (L), moderate (M), and deep (D) anesthesia were 0.40 +/- 0.05 (mean +/- SE), 0.24 +/- 0.03, and 0.10 +/- 0.02, respectively, and were significantly different from each other. Under each grade of anesthesia, exercise was performed by electrically stimulating the bilateral femoral and sciatic nerves for 4 min. The time to reach 63% of full response of the increase in ventilation (tauVE) after beginning of exercise was 28.3 +/- 1.5, 38.1 +/- 5.2, and 56.0 +/- 6.1 s in L, M, and D, respectively. During steady-state exercise, minute ventilation (VE) in L, M, and D significantly increased to 6.17 +/- 0.39, 5.14 +/- 0.30, and 3.41 +/- 0.16 1 X min-1, from resting values of 3.93 +/- 0.34, 2.97 +/- 0.17, and 1.69 +/- 0.14 1 X min-1, respectively, while end-tidal CO2 tension (PETCO2) in L decreased significantly to 34.8 +/- 0.9 from 35.7 +/- 0.9, did not change in M (38.9 +/- 1.1 from 38.9 +/- 0.8), and increased significantly in D to 47.3 +/- 1.9 from 45.1 +/- 1.7 Torr.(ABSTRACT TRUNCATED AT 250 WORDS)