Normal tissue complication probability modeling for acute esophagitis in patients treated with conformal radiation therapy for non-small cell lung cancer
Normal tissue complication probability modeling for acute esophagitis in patients treated with conformal radiation therapy for non-small cell lung cancer
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DOI：
10.1016/j.radonc.2005.10.001
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发表时间：
2005-11-01
影响因子：
5.7
通讯作者：
Ten Haken, RK
中科院分区：
文献类型：
--
作者：
Chapet, O;Kong, FM;Ten Haken, RK
目的：通过确定更新的模型参数，然后将这些结果与其他剂量学参数的预测值进行比较，评估众所周知的正常组织并发症概率 (NTCP) 模型预测放射性食管炎的能力。材料和方法：对 101 名接受外照射治疗的不能手术/不可切除的非小细胞肺癌患者进行食管炎的临床和剂量学数据进行分析。 2 级或以上食管炎计为事件。使用最大似然分析确定莱曼正常组织并发症概率 (NTCP) 模型的参数（TD50、n 和 m），并与其他剂量/体积阈值进行比较，包括：接受 > 40 Gy (V40) 至 > 75 Gy (V75) 的食管百分比，以及最大食管剂量。 结果：16 名患者出现 2-3 级急性食管炎（无 G4 或 5）。最大似然分析产生新的莱曼模型参数：TD50 = 51 Gy，n = 0.44 和 m = 0.32。平均 NTCP 值显着较低 (P
Purpose: To evaluate the ability of a well-known normal tissue complication probability (NTCP) model to predict radiation esophagitis by determining updated model parameters and then comparing these results with the predictive value of other dosimetric parameters.Material and methods: Clinical and dosimetric data regarding esophagitis were analyzed in 101 inoperable/unresectable non-small-cell lung cancer patients treated by external beam irradiation. Grade 2 or higher esophagitis counted as events. Parameters (TD50, n, and m) of the Lyman normal tissue complication probability (NTCP) model were determined using maximum likelihood analysis, and compared to other dose/volume threshold values including: percentage of esophagus receiving > 40 Gy (V40) to > 75 Gy (V75), and maximum esophageal doses.Results: Sixteen patients developed grade 2-3 acute esophagitis (no G4 or 5). The maximum likelihood analysis produced new Lyman model parameters of: TD50 = 51 Gy, n = 0.44 and m = 0.32. The mean NTCP value is significantly lower (P