Alternative splicing produces transcripts encoding two forms of the alpha subunit of GTP-binding protein Go.
Alternative splicing produces transcripts encoding two forms of the alpha subunit of GTP-binding protein Go.
复制标题
选择性剪接产生编码两种形式的 GTP 结合蛋白 Go α 亚基的转录物。
DOI：
10.1073/pnas.87.17.6477
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发表时间：
1990
影响因子：
11.1
通讯作者：
Simon,MI
中科院分区：
文献类型：
--
作者：
Strathmann,M;Wilkie,TM;Simon,MI
鸟嘌呤核苷酸结合蛋白Go的α亚基（“o”表示其他）被认为介导多种受体和效应器之间的信号转导。从小鼠脑文库中分离到编码两种形式Go α亚基的cDNA克隆。这两种形式，我们称之为GoA α和GoB α，似乎是选择性剪接的产物。GoA α与GoB α在推断的蛋白序列的c端三分之一处不同。预测这两种形式都是百日咳毒素adp核糖基化的底物。GoA α转录本存在于多种组织中，但在大脑中最为丰富。GoB α转录本在大脑和睾丸中表达水平最高。GoA α和GoB α可能有不同的功能。
The alpha subunit of the guanine nucleotide-binding protein Go ("o" for other) is believed to mediate signal transduction between a variety of receptors and effectors. cDNA clones encoding two forms of Go alpha subunit were isolated from a mouse brain library. These two forms, which we call GoA alpha and GoB alpha, appear to be the products of alternative splicing. GoA alpha differs from GoB alpha over the C-terminal third of the deduced protein sequence. Both forms are predicted to be substrates for ADP-ribosylation by pertussis toxin. GoA alpha transcripts are present in a variety of tissues but are most abundant in brain. The GoB alpha transcript is expressed at highest levels in brain and testis. It is possible that GoA alpha and GoB alpha have different functions.