Polymeric gene delivery for diabetic treatment.
Polymeric gene delivery for diabetic treatment.
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DOI：
10.4093/dmj.2011.35.4.317
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发表时间：
2011-08
影响因子：
5.9
通讯作者：
Kim SW
中科院分区：
文献类型：
--
作者：
Kim SW
几种聚合物被用于向糖尿病动物递送基因。利用聚氨基丁基乙醇酸（polyaminobutylglycolic acid，PABA）载体介导IL-10质粒DNA，预防非肥胖型糖尿病（nonobese diabetic，NOD）小鼠自身免疫性胰岛炎。聚乙二醇接枝聚赖氨酸与反义谷氨酸脱羧酶（GAD）mRNA结合，代表GAD自身抗原表达。GLP 1和TSTA（SP-EX 4）通过生物可还原聚合物递送以阻止糖尿病进展。实施Fas siRNA递送以治疗糖尿病NOD小鼠动物。
Several polymers were used to delivery genes to diabetic animals. Polyaminobutyl glycolic acid was utilized to deliver IL-10 plasmid DNA to prevent autoimmune insulitis of non-obese diabetic (NOD) mouse. Polyethylene glycol grafted polylysine was combined with antisense glutamic acid decarboxylase (GAD) MRNA to represent GAD autoantigene expression. GLP1 and TSTA (SP-EX4) were delivered by bioreducible polymer to stop diabetic progression. Fas siRNA delivery was carried out to treat diabetic NOD mice animal.