The Role of the Augmin Complex in Establishing Microtubule Arrays.
The Role of the Augmin Complex in Establishing Microtubule Arrays.
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DOI：
10.1093/jxb/erz123
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发表时间：
2019-06
影响因子：
6.9
通讯作者：
Juan Tian;Zhaosheng Kong
中科院分区：
文献类型：
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作者：
Juan Tian;Zhaosheng Kong
微管（MT）依赖的MT成核发生在预先存在的MT的侧表面上，并提供了一种高效的手段，放大MT群体和重组MT架构。微管蛋白环复合物（TuRC）作为模板启动新生MT聚合。augmin是一种异源八聚体蛋白复合物，它作为一种招募因子将TuRC靶向于已存在的MT并引发新的MT生长。虽然MT依赖的MT成核已在动物和植物细胞中被广泛研究，但尚不清楚Augmin复合物如何在植物细胞中组装，特别是在细胞周期和细胞类型特异性方式中，以及其空间结构如何协调成核几何形状。在这篇综述中，我们总结了Augmin依赖的MT成核及其几何调控的进展，并强调了最近的研究结果和新出现的问题有关的Augmin复合物在建立MT阵列和其细胞周期特异性组合物在植物细胞中的作用。
Microtubule (MT)-dependent MT nucleation occurs on the lateral surface of pre-existing MTs and provides a highly efficient means of amplifying MT populations and reorganizing MT architectures. The ‑tubulin ring complex (TuRC) serves as the template to initiate nascent MT polymerization. And augmin, a hetero-octameric protein complex, acts as a recruiting factor to target TuRC to pre-existing MTs and trigger new MT growth. Although MT-dependent MT nucleation has been extensively studied in both animal and plant cells, it remains unclear how the augmin complex assembles in plant cells, especially in cell cycle- and cell type-specific manners, and how its spatial structure orchestrates the nucleation geometry. In this review, we summarize the advances of augmin-dependent MT nucleation and its geometry regulation, and highlight recent findings and emerging questions concerning the role of the augmin complex in establishing MT arrays and its cell cycle-specific compositions in plant cells.