Antisense RNA to the c-fos gene: restoration of density-dependent growth arrest in a transformed cell line.
Antisense RNA to the c-fos gene: restoration of density-dependent growth arrest in a transformed cell line.
复制标题
c-fos 基因的反义 RNA：在转化细胞系中恢复密度依赖性生长停滞。
DOI：
10.1016/s0006-291x(87)80119-5
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发表时间：
1987
影响因子：
3.1
通讯作者：
Edwards,SA
中科院分区：
文献类型：
--
作者：
Mercola,D;Rundell,A;Westwick,J;Edwards,SA
相对于未转化的对照，v-sis转化的成纤维细胞具有升高的c-fos水平。转染和整合的质粒指导合成的反义RNA的c-fos基因导致恢复密度依赖性生长停滞在单层培养，但不抑制软琼脂中的集落形成。
Fibroblasts transformed by v-sis have elevated levels of c-fos relative to non-transformed controls. Transfection and integration of plasmids directing the synthesis of antisense RNA to the c-fos gene leads to restoration of density-dependent growth arrest in monolayer culture, but does not inhibit colony formation in soft agar.