Reduced selection for codon usage bias in Drosophila miranda
Reduced selection for codon usage bias in Drosophila miranda
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DOI：
10.1007/s00239-006-0257-x
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发表时间：
2007-05-01
影响因子：
3.9
通讯作者：
Bachtrog, Doris
中科院分区：
文献类型：
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作者：
Bachtrog, Doris
在许多物种中，密码子的使用偏向是由于突变、弱选择和遗传漂变之间的平衡。在这里，我表明，选择，以保持有偏见的密码子使用减少果蝇米兰达相对于它的祖先。对非编码DNA突变模式的分析表明，这种减少的程度不能用突变偏倚的变化或偏倚的基因转换来解释。低水平的变异性D。米兰达相对于其姊妹种D. pseudobscura，表明它有一个小得多的有效人口规模。降低D.因此，米兰达可能是由于针对新出现的突变选择到非优选密码子的效力降低而导致的。
Biased codon usage in many species results from a balance among mutation, weak selection, and genetic drift. Here I show that selection to maintain biased codon usage is reduced in Drosophila miranda relative to its ancestor. Analyses of mutation patterns in noncoding DNA suggest that the extent of this reduction cannot be explained by changes in mutation bias or by biased gene conversion. Low levels of variability in D. miranda relative to its sibling species, D. pseudoobscura, suggest that it has a much smaller effective population size. Reduced codon usage bias in D. miranda may thus result from the reduced efficacy of selection against newly arising mutations to unpreferred codons.