COMPARISON OF LASER PHOTOCOAGULATION FOR DIABETIC RETINOPATHY USING 532-NM STANDARD LASER VERSUS MULTISPOT PATTERN SCAN LASER
COMPARISON OF LASER PHOTOCOAGULATION FOR DIABETIC RETINOPATHY USING 532-NM STANDARD LASER VERSUS MULTISPOT PATTERN SCAN LASER
复制标题
DOI：
10.1097/iae.0b013e3181c70127
复制
发表时间：
2010-03-01
影响因子：
3.3
通讯作者：
Nagpal, Kamal
中科院分区：
文献类型：
--
作者：
Nagpal, Manish;Marlecha, Sangita;Nagpal, Kamal
目的：本研究的目的是比较532 nm固态绿色激光（GLX）与多点532 nm模式扫描激光（PASCAL）对增殖性糖尿病视网膜病变或严重非增殖性糖尿病视网膜病变的全视网膜光凝治疗的疗效、间接损伤和便利性。方法：本研究为前瞻性随机临床试验。60例患有双侧对称增殖性糖尿病视网膜病变或严重非增殖性糖尿病视网膜病变的患者参与了研究。每位患者接受全视网膜光凝治疗：一只眼使用GLX，另一只眼使用PASCAL，每只眼坐两次。两种方式均可放置200 μ m斑点大小的三级烧伤。比较两组患者的影响程度、疼痛感（视觉模拟量表）、时间、激光光斑分布（红外图像）和视网膜敏感度。结果：模式扫描激光和GLX所需的平均能量分别为40.33和191 J/cm(2)。每次静坐所需的平均时间，PASCAL为1.43分钟，GLX为4.53分钟。GLX的平均视觉模拟刻度读数为4.6，而PASCAL为0.33。Heidelberg视网膜血管造影图像显示，GLX和PASCAL治疗3个月时，斑点扩散为430 μ m，而不是310 μ m。PASCAL组在中央15度和15度至30度区域的平均视网膜敏感度分别为25.08和22.08 dB，高于GLX组（23.16和17.14 dB）。结论：与GLX相比，激光模式扫描的视网膜病变附带损害较小，消退相似。与GLX相比，模式扫描激光治疗耗时更短，疼痛更少。中国生物医学工程学报（英文版），2010
Purpose: The purpose of this study was to compare the efficacy, collateral damage, and convenience of panretinal photocoagulation for proliferative diabetic retinopathy or severe nonproliferative diabetic retinopathy using a 532-nm solid-state green laser (GLX) versus a multispot 532-nm pattern scan laser (PASCAL).Methods: This study was a prospective randomized clinical trial. Sixty patients with bilaterally symmetrical proliferative diabetic retinopathy or severe nonproliferative diabetic retinopathy participated. Each patient underwent panretinal photocoagulation: one eye with GLX and the other with PASCAL, two sittings per eye. Grade 3 burns with a 200-mu m spot size were placed with both modalities. The fluence, pain using the visual analog scale, time, laser spot spread with infrared images, and retinal sensitivity were compared.Results: Pattern scan laser and GLX required an average fluence of 40.33 vs 191 J/cm(2), respectively. Average time required per sitting was 1.43 minutes with PASCAL and 4.53 minutes with GLX. Average visual analog scale reading for GLX was 4.6, whereas that for PASCAL was 0.33. Heidelberg retinal angiography images showed the spot spread as being 430 versus 310 mu m at 3 months with GLX and PASCAL. The eyes treated with PASCAL showed higher average retinal sensitivity in the central 15 degrees and 15 degrees to 30 degrees zones (25.08 and 22.08 dB, respectively) than the eyes treated with GLX (23.16 and 17.14 dB), respectively.Conclusion: Pattern scan laser showed lesser collateral damage and similar regression of retinopathy compared with GLX. Pattern scan laser treatment was less time consuming and less painful for the patient compared with GLX. RETINA 30: 452-458, 2010