The effect of urinary cadmium on cardiovascular fitness as measured by VO2 max in white, black and Mexican Americans
The effect of urinary cadmium on cardiovascular fitness as measured by VO2 max in white, black and Mexican Americans
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DOI：
10.1016/j.envres.2008.11.010
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发表时间：
2009-04-01
影响因子：
8.3
通讯作者：
Goodfellow, Lynda
中科院分区：
文献类型：
--
作者：
Egwuogu, Heartley;Shendell, Derek G.;Goodfellow, Lynda
目的：我们探讨了镉暴露对心血管健康的措施，包括性别和种族/ethnic difficulties.Methods的潜在影响：数据来自1999年至2000年全国健康与营养检查调查（NHANES），1963参与主题包括在我们的分析。在一系列分级运动中记录次最大活动（VO 2 max）时的耗氧量;目标是获得75%的预定年龄特异性心率。在实验室使用标准方法测量尿样中的镉。多元线性回归分析进行，以确定潜在的relationships.Results：尿镉浓度增加一般与估计VO 2最大值下降。还观察到性别和种族/民族差异。具体而言，协会有统计学意义的白色男性和墨西哥裔美国femines.Conclusion：尿镉浓度和估计VO 2最大值之间的负相关性进行了观察，包括种族和性别差异。这种性别和种族/民族差异对长期心血管健康和目前公共卫生关注的健康差异的影响值得进一步研究。(C)2008年爱思唯尔公司All rights reserved.
Objectives: We explored potential effects of cadmium exposure on cardiovascular fitness measures, including gender and racial/ethnic differences.Methods: Data were from the 1999 to 2000 National Health and Nutrition Examination Survey (NHANES); 1963 participating subjects were included in our analysis. Volume of oxygen consumed at sub-maximum activity (VO2 max) were recorded in a series of graded exercises; the goal was to elicit 75% of predetermined age-specific heart rates. Cadmium from urine samples was measured in the laboratory using standard methods. Multivariate linear regression analyses were performed to determine potential relationships.Results: Increased urinary cadmium concentrations were generally associated with decreased estimated VO2 max values. Gender and racial/ethnic differences were also observed. Specifically, associations were statistically significant for white males and Mexican American females.Conclusion: Inverse associations between urinary cadmium concentrations and estimated VO2 max values were observed, including racial and gender differences. The implications of such gender and racial/ethnic differences on long-term cardiovascular health and health disparities of present public health concern warrant further investigation. (C) 2008 Elsevier Inc. All rights reserved.