How valid is using cancer registries' data to identify acquired immunodeficiency syndrome-related non-Hodgkin's lymphoma?
How valid is using cancer registries' data to identify acquired immunodeficiency syndrome-related non-Hodgkin's lymphoma?
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使用癌症登记数据来识别获得性免疫缺陷综合征相关的非霍奇金淋巴瘤的有效性如何？
DOI：
10.1007/s10552-006-0096-5
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
Anton-Culver,Hoda
中科院分区：
文献类型：
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作者：
Diamond,Catherine;Taylor,ThomasH;Im,Theresa;Wallace,Mark;Saven,Alan;Anton-Culver,Hoda
目的我们试图确定关于非霍奇金淋巴瘤 (NHL) 患者的人类免疫缺陷病毒 (HIV)/获得性免疫缺陷综合征 (AIDS) 状态的癌症登记数据的准确性。方法我们使用基于人群的圣地亚哥/奥兰治县癌症登记处来识别 1994-1999 年间诊断的 392 名 HIV 相关 NHL 患者。在对年龄、性别、种族、NHL诊断时间和医院类型进行匹配后，我们在1994-1999年诊断的剩余4,863名NHL患者（根据癌症登记记录没有感染HIV）中找到了324名对应的患者。我们试图通过 15 个独立的机构审查委员会审查 41 家医院的这些患者的图表，以确定癌症登记处的 HIV 血清状态是否正确。我们进行了前向条件多元逻辑回归以确定与假阳性 HIV 状态相关的特征。结果假阳性率为 8%，假阴性率为 3%。阳性预测值为93%，阴性预测值为97%。与正确识别的患者相比，假阳性患者更有可能是年龄≥50 岁、女性且接受过化疗的患者，而不太可能是患有重度或结外疾病的单身患者。 结论 使用癌症登记数据来识别 AIDS 相关的 NHL 是一种有效的研究实践。
ObjectiveWe sought to determine the accuracy of cancer registry data regarding the human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) status of patients with non-Hodgkin’s lymphoma (NHL).MethodsWe used the population-based San Diego/Orange County cancer registry to identify 392 patients with HIV-related NHL diagnosed 1994–1999. After matching for age, sex, race, period of NHL diagnosis, and hospital type, we were able to find 324 corresponding patients among the remaining 4,863 NHL patients diagnosed 1994–1999 (who did not have HIV infection according to cancer registry records). We sought to review these patients’ charts at 41 hospitals with 15 separate institutional review boards to determine if the HIV serostatus from the cancer registry was correct. We performed a forward conditional multivariate logistic regression to determine characteristics associated with a false positive HIV status.ResultsThe false positive rate was 8% while the false negative rate was 3%. The positive predictive value was 93% while the negative predictive value was 97%. Compared to correctly identified patients, false positives were more likely to be ≥50 years old, female, and treated with chemotherapy and less likely to be single with high grade or extranodal disease.ConclusionUsing cancer registry data to identify AIDS-related NHL is a valid research practice.