Rescue of cAMP Response Element‐Binding Protein Signaling Reversed Spatial Memory Retention Impairments Induced by Subanesthetic Dose of Propofol
Rescue of cAMP Response Element‐Binding Protein Signaling Reversed Spatial Memory Retention Impairments Induced by Subanesthetic Dose of Propofol
复制标题
DOI：
10.1111/cns.12088
复制
发表时间：
2013-07
影响因子：
5.5
通讯作者：
H. Zhang;Shao-bo Zhang;Qing-qing Zhang;Meng Liu;Xing-ying He;Z. Zou;Hai-jing Sun;Zhen-dong You-
中科院分区：
文献类型：
--
作者：
H. Zhang;Shao-bo Zhang;Qing-qing Zhang;Meng Liu;Xing-ying He;Z. Zou;Hai-jing Sun;Zhen-dong You-
静脉麻醉药异丙酚可引起人类情节记忆障碍。我们假设丙泊酚引起大鼠的情景样空间记忆保持，但不是获得障碍，使用选择性IV型磷酸二酯酶（PDEIV）抑制剂咯利普兰拯救cAMP反应元件结合蛋白（CREB）信号转导可逆转这些效应。
The intravenous anesthetic propofol caused episodic memory impairments in human. We hypothesized propofol caused episodic‐like spatial memory retention but not acquisition impairments in rats and rescuing cAMP response element‐binding protein (CREB) signaling using selective type IV phosphodiesterase (PDEIV) inhibitor rolipram reversed these effects.