T cell receptor signaling precedes immunological synapse formation
T cell receptor signaling precedes immunological synapse formation
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DOI：
10.1126/science.1067710
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发表时间：
2002-02-22
期刊：
影响因子：
56.9
通讯作者：
Shaw, AS
中科院分区：
文献类型：
--
作者：
Lee, KH;Holdorf, AD;Shaw, AS
T细胞和抗原呈递细胞（APC）之间的接触区域被称为免疫突触。尽管其确切功能尚不清楚，但一种模型表明，它允许T细胞受体（TCR）聚集并在T细胞中持续数小时的信号传导。在这里，我们证明了TCR介导的酪氨酸激酶信号转导在幼稚T细胞主要发生在突触的外周，并在成熟的免疫突触形成之前大大减弱。这些数据表明，T细胞活化不需要许多小时的TCR信号传导。这些观察结果挑战了目前关于免疫突触在T细胞活化中的作用的观点。
The area of contact between a T cell and an antigen-presenting cell (APC) is known as the immunological synapse. Although its exact function is unknown, one model suggests that it allows for T cell receptor (TCR) clustering and for sustained signaling in T cells for many hours. Here we demonstrate that TCR-mediated tyrosine kinase signaling in naive T cells occurred primarily at the periphery of the synapse and was largely abated before mature immunological synapses had formed. These data suggest that many hours of TCR signaling are not required for T cell activation. These observations challenge current ideas about the role of immunological synapses in T cell activation.