Overexpression of α-synuclein following methamphetamine -: Is it good or bad?
Overexpression of α-synuclein following methamphetamine -: Is it good or bad?
复制标题
DOI：
10.1196/annals.1369.019
复制
发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Fornai, Francesco
中科院分区：
文献类型：
--
作者：
Mauceli, Giuseppe;Busceti, Carla I.;Fornai, Francesco
α-突触核蛋白是一种突触前蛋白，参与各种退行性疾病，现在被定义为突触核蛋白病。这些包括共享由特定神经元群体和/或神经胶质细胞内的正常和改变的α-突触核蛋白的聚集体组成的一些病理特征的神经系统疾病。突触核蛋白病的原型是帕金森病（PD），其中α-突触核蛋白被鉴定为神经元苍白嗜酸性包涵体的恒定组分：“路易体”。“在本文中，我们讨论了安非他明诱导的α-突触核蛋白过表达的潜在意义，根据临床结果显示α-突触核蛋白过表达后神经变性和最近的实验研究，测量安非他明衍生物后α-突触核蛋白表达增加。
alpha-Synuclein is a presynaptic protein involved in various degenerative disorders now defined as synucleinopathies.. These include neurological diseases that share a few pathological features consisting of aggregates of both normal and altered alpha-synuclein within specific neuronal populations and/or glial cells. The prototype of synucleinopathies is represented by Parkinson's disease (PD) in which alpha-synuclein is identified as a constant component of neuronal pale eosinophilic inclusions: "the Lewy Bodies." In the present article, we discuss the potential significance of amphetamine-induced overexpression of alpha-synuclein in light of clinical findings showing neurodegeneration following overexpression of alpha-synuclein and recent experimental studies that measured increased expression of alpha-synuclein following amphetamine derivatives.