Experimental Subarachnoid Hemorrhage: Double Cisterna Magna Injection Rat Model-Assessment of Delayed Pathological Effects of Cerebral Vasospasm
Experimental Subarachnoid Hemorrhage: Double Cisterna Magna Injection Rat Model-Assessment of Delayed Pathological Effects of Cerebral Vasospasm
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DOI：
10.1007/s12975-015-0392-z
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发表时间：
2015-06-01
影响因子：
6.9
通讯作者：
Vatter, Hartmut
中科院分区：
文献类型：
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作者：
Gueresir, Erdem;Schuss, Patrick;Vatter, Hartmut
动脉瘤性蛛网膜下腔出血包括出血后的早期阶段和出血延迟后果的晚期阶段。延迟性损伤机制的发展，如脑血管痉挛（CVS）引起的脑血流量减少（CBF），似乎主要取决于蛛网膜下腔血块的数量和持续时间。脑血流减少可导致脑缺血和迟发性神经功能恶化。大鼠双大池注射模型比其他啮齿动物蛛网膜下腔出血模型更准确地再现了CVS延迟后果的时间过程和临床环境。因此，大鼠双大池注射模型似乎倾向于用于模拟蛛网膜下腔出血的延迟后果。我们回顾了现有的关于该动物模型的文献，并提出了一个标准的方案，包括技术方面的考虑，以及该模型的优点和局限性。
Aneurysmal subarachnoid hemorrhage comprises of an early phase after the bleeding and a late phase of delayed consequences of the bleeding. The development of delayed injury mechanisms, like the reduction of cerebral blood flow (CBF) due to cerebral vasospasm (CVS), seems mainly to depend on the amount and the duration of the subarachnoid blood clot. The reduction of CBF may lead to cerebral ischemia and delayed neurological deterioration. The rat double cisterna magna injection model reproduces the time course of the delayed consequences of CVS and imitates the clinical setting more precise than other rodent subarachnoid hemorrhage models. Therefore, the rat double cisterna magna injection model seems to be predisposed to be used to mimick the delayed consequences of subarachnoid hemorrhage. We reviewed the existing literature on this animal model and propose a standard protocol including technical considerations, as well as advantages and limitations of this model.