Effect of treatment of chronic periodontitis on levels of serum markers of acute-phase inflammatory and vascular responses
Effect of treatment of chronic periodontitis on levels of serum markers of acute-phase inflammatory and vascular responses
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DOI：
10.1034/j.1600-051x.2003.00282.x
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发表时间：
2003-04-01
影响因子：
6.7
通讯作者：
Wilson, RF
中科院分区：
文献类型：
--
作者：
Ide, M;McPartlin, D;Wilson, RF
目的：最近的流行病学研究表明，牙周病的严重程度和心血管疾病的风险之间的关联。本研究旨在确定循环水平的心血管和全身炎症标志物可以修改以下治疗牙周diseases.Method：成年受试者被招募从那些等待牙周治疗和随机立即（测试，n = 24）或延迟治疗（对照，n = 15）。收集人口统计学和临床数据，并在治疗前和治疗完成后6周或同等的3个月对照期后采集静脉血。牙周检查包括探诊深度、附着丧失、斑块评分和出血评分。分析血液以测定血清和血浆纤维蛋白原、C-反应蛋白、唾液酸、肿瘤坏死因子-α和白细胞介素-6和-1 β。通过配对检验和方差分析评估治疗组与基线covariates.Results的治疗效果：治疗改善斑块和出血评分，减少探诊深度（P < 0.002）。然而，有没有统计学上的显着变化水平的任何系统marker.Conclusion：牙周健康的改善并没有影响血管标记物的水平。
Aims: Recent epidemiological work suggests an association between periodontal disease severity and cardiovascular disease risk. This study aimed to ascertain if circulating levels of cardiovascular and systemic inflammatory markers could be modified following treatment of periodontal disease.Method: Adult subjects were recruited from those awaiting periodontal treatment and randomised to either immediate (test, n = 24) or delayed treatment (control, n = 15). Demographic and clinical data were collected and venous blood was taken before and either 6 weeks after completion of treatment or after an equivalent 3-month control period. Periodontal examination included probing depth, loss of attachment, plaque scores and bleeding scores. Blood was analysed to determine serum and plasma fibrinogen, C-reactive protein, sialic acid, tumour necrosis factor-alpha and interleukin -6 and -1beta. Effects of treatment were assessed by paired tests and analysis of variance by treatment group with baseline covariates.Results: Treatment improved plaque and bleeding scores and reduced probing depths (p < 0.002). However, there were no statistically significant changes in levels of any of the systemic markers.Conclusion: Improvement in periodontal health did not influence the levels of vascular markers.