Transition metal abnormalities in progressive dementias
Transition metal abnormalities in progressive dementias
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DOI：
10.1007/s10534-011-9504-8
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发表时间：
2012-04-01
期刊：
影响因子：
3.5
通讯作者：
Yezdimer, Eric M.
中科院分区：
文献类型：
--
作者：
Akatsu, Hiroyasu;Hori, Akira;Yezdimer, Eric M.
脑内过渡金属的异常分布是几种中枢神经系统疾病的潜在诊断标志物，包括阿尔茨海默病（AD）、帕金森病、路易体痴呆（DLB）、双相情感障碍和抑郁症。为了进一步探索这种可能性，铁，锌，铜，锰，铝，铬和镉的总浓度进行了测量，从AD，DLB和对照患者的死后海马和杏仁核组织。在海马和杏仁核中观察到AD患者的总铜水平在统计学上显著降低近50%。海马和杏仁核铜分析的统计功效分别为86%和74%。对于锌、锰、铬或铝，未发现总金属浓度的统计学显著偏差。铁被发现增加了38%，在AD杏仁核组织，但在AD海马组织不变。考虑到组织含水量的差异，作为组织类型和疾病状态的函数，揭示了与先前文献更多的相似性。为了帮助设计未来的实验，所有组织类型和研究的金属的效果大小也提出。
Abnormal distributions of transition metals inside the brain are potential diagnostic markers for several central nervous system diseases, including Alzheimer's disease (AD), Parkinson's disease, dementia with Lewy bodies (DLB), bipolar disorders and depression. To further explore this possibility, the total concentrations of iron, zinc, copper, manganese, aluminum, chromium and cadmium were measured in post-mortem hippocampus and amygdala tissues taken from AD, DLB and Control patients. A statistically significant near fifty percent reduction in the total copper levels of AD patients was observed in both the hippocampus and amygdala. The statistical power of the hippocampus and amygdala copper analysis was found to be 86 and 74% respectively. No statistically significant deviations in the total metal concentrations were found for zinc, manganese, chromium or aluminum. Iron was found to be increased by 38% in AD amygdala tissues, but was unchanged in AD hippocampus tissues. Accounting for differences in tissue water content, as a function of both tissue type and disease state, revealed more consistencies with previous literature. To aid in the design of future experiments, the effect sizes for all tissue types and metals studied are also presented.