Regulation of the biosynthesis of 22:5n-6 and 22:6n-3: A complex intracellular process
Regulation of the biosynthesis of 22:5n-6 and 22:6n-3: A complex intracellular process
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DOI：
10.1007/bf02562271
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发表时间：
2007
期刊：
影响因子：
1.9
通讯作者：
H. Sprecher;Qi Chen;F. Q. Yin
中科院分区：
文献类型：
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作者：
H. Sprecher;Qi Chen;F. Q. Yin
22：4 n-6和22：5 n-3均由内质网中的n-6和n-3脂肪酸前体合成。22：5 n-6和22：6 n-3的合成需要22：4 n-6和22：5 n-3在内质网中分别代谢为24：5 n-6和24：6 n-3。这两种24-碳酸必须移动到过氧化物酶体进行部分降解，然后将22：5 n-6和22：6 n-3移动回内质网，用作膜脂质生物合成的底物。显然，了解细胞内脂肪酸运动的控制以及微粒体、过氧化物酶体和线粒体进行的反应都是必要的，以便不仅了解是什么调节22：5 n-6和22：6 n-3的生物合成，而且了解为什么大多数组织脂质选择性地积累22：6 n-3。
Both 22:4n‐6 and 22:5n‐3 are synthesized from n‐6 and n‐3 fatty acid precursors in the endoplasmic reticulum. The synthesis of both 22:5n‐6 and 22:6n‐3 requires that 22:4n‐6 and 22:5n‐3 are metabolized, respectively, to 24:5n‐6 and 24:6n‐3 in the endoplasmic reticulum. These two 24‐carbon acids must then move to peroxisomes for partial degradation followed by the movement of 22:5n‐6 and 22:6n‐3 back to the endoplasmic reticulum for use as substrates in membrane lipid biosynthesis. Clearly an understanding of the control of intracellular fatty acid movement as well as of the reactions carried out by microsomes, peroxisomes, and mitochondria are all required in order to understand not only what regulates the biosynthesis of 22:5n‐6 and 22:6n‐3 but also why most tissue lipids selectively accumulate 22:6n‐3.