VITAMIN-A, DIFFERENTIATION AND CANCER
VITAMIN-A, DIFFERENTIATION AND CANCER
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DOI：
10.1016/0955-0674(94)90051-5
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发表时间：
1994-12-01
影响因子：
7.5
通讯作者：
GUDAS, LJ
中科院分区：
文献类型：
--
作者：
LOVE, JM;GUDAS, LJ
维甲酸是维生素A的衍生物，在正常细胞分化和癌症发生过程中有多种作用。最近发现了一些新的内源性视黄醇代谢物。许多细胞类型对维甲酸治疗的反应是由维甲酸受体介导的，涉及基因表达、细胞生长和细胞分化的变化。编码一种维甲酸受体的基因被与急性早幼粒细胞白血病相关的染色体易位破坏，另一种受体的表达在上皮性肿瘤中发生改变；这两个发现都对维甲酸类化合物作为抗癌药物的使用具有重要意义。最近已经证明，某些同源框基因是由维甲酸调节的；这些基因也可能被证明是抗癌治疗的有用药物。
Retinoids, which are derivatives of vitamin A, have a variety of effects on normal cellular differentiation and on the process of carcinogenesis. A number of novel endogenous retinol metabolites have been identified recently. The response of many cell types to retinoid treatment is mediated by retinoid receptors, and involves changes in gene expression, cell growth and cell differentiation. The gene encoding one of the retinoic acid receptors is disrupted by the chromosome translocations associated with acute promyelocytic leukemia, and the expression of another is altered in epithelial tumors; both of these findings have important implications for the use of retinoids as anti-carcinogenic agents. It has been demonstrated recently that certain homeobox genes are regulated by retinoids; these genes may also prove to be useful agents for anti-carcinogenic therapies.