LOW-DOSES OF ETHANOL IMPAIR SPATIAL WORKING-MEMORY AND REDUCE HIPPOCAMPAL THETA-ACTIVITY
LOW-DOSES OF ETHANOL IMPAIR SPATIAL WORKING-MEMORY AND REDUCE HIPPOCAMPAL THETA-ACTIVITY
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DOI：
10.1111/j.1530-0277.1995.tb01580.x
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发表时间：
1995-06-01
影响因子：
3.2
通讯作者：
GIVENS, B
中科院分区：
文献类型：
--
作者：
GIVENS, B
低剂量的乙醇可以改变隔海马通路的神经活动，这是空间工作记忆的关键通路。本研究旨在确定急性乙醇是否会引起工作记忆障碍，并通过海马theta节律测定破坏隔海马功能。术前对大鼠进行延迟交替训练。采用受试者内设计评价注射乙醇（0.25、0.5、0.75和1.0 g/kg，腹腔注射）后10 min和90 min与注射前基线相比对性能的影响。乙醇产生的剂量，延迟，和时间依赖性损害工作记忆的变化所示的选择准确性在延迟交替任务。乙醇不影响执行时间，完成任务的能力，或响应偏差。因此，这种损伤似乎不是由于一般表现的下降，而是由于空间工作记忆的损伤。海马theta活动抑制乙醇在相同的剂量，0.75 g/kg和1.0 g/kg，损害工作记忆。乙醇与隔海马通路的功能的相互作用进行了讨论。
Low doses of ethanol can alter neural activity in the septohippocampal pathway, a pathway critical for spatial working memory. The present study was designed to determine whether acute ethanol induces impairments in working memory and disrupts septohippocampal function as measured by the hippocampal theta rhythm. Rats were preoperatively trained on delayed alternation. A within-subject design was used to evaluate the effects of ethanol (0.25, 0.5, 0.75 and 1.0 g/kg, intraperitoneally) on performance 10 min and 90 min after injection as compared with preinjection baseline. Ethanol produced dose-, delay-, and time-dependent impairments in working memory as indicated by a change in choice accuracy in the delayed alternation task. Ethanol did not affect performance time, the ability to complete the task, or response bias. Thus, the impairment does not appear to result from a decrement in general performance, but rather from an impairment in spatial working memory. Hippocampal theta activity was suppressed by ethanol at the same doses, 0.75 g/kg and 1.0 g/kg, that impaired working memory. The interaction of ethanol with functions of the septohippocampal pathway are discussed.