The relationship between t and H-2 complexes in wild mice. I. The H-2 haplotypes of 20 t-bearing strains.
The relationship between t and H-2 complexes in wild mice. I. The H-2 haplotypes of 20 t-bearing strains.
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野生小鼠中 t 和 H-2 复合物之间的关系。
DOI：
10.1017/s0016672300018929
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Klein,J
中科院分区：
文献类型：
--
作者：
Sturm,S;Figueroa,F;Klein,J
从欧洲、以色列、北非和南美洲多个地点捕获的野生小鼠中提取了二十个单倍型。单倍型被指定为 tTuw1 至 tTuw20。这些品系的H-2单倍型是使用抗血清和单克隆抗体来定义的，这些抗血清和单克隆抗体对已知H-2等位基因控制的私有抗原决定簇以及使用新的t品系作为供体产生的抗血清进行控制。 tTuw 单倍型根据与其相关的 H-2 单倍型分为四组。单倍型 tTuw10 到 tTuw18 与 H-2W30 相关，此前发现与 tw1 组的单倍型相关。单倍型 tTuw1 至 tTuw6 与新的 H-2 单倍型 H-2w36 相关，其特征在于决定簇 H-2.107。单倍型 tTuw7 至 tTuw9 与另一种新的 H-2 单倍型 H-2w37 相关，其特征在于决定簇 H-2.108 和 H-2.111。最后，单倍型 tTuw19 和 tTuw20 与另一种新的 H-2 单倍型 H-2w38 相关，其特征在于决定簇 H-2.33 和 H-2.109。这些发现表明，t 多态性可能比以前认为的更广泛、更复杂，并且至少一些 t 相关的 H-2 单倍型，可能还有 t 单倍型本身，在起源上彼此相关。
Twenty t haplotypes were extracted from wild mice captured at several locations in Europe, Israel, North Africa, and South America. The haplotypes were designated tTuw1 through tTuw20. The H-2 haplotypes of the lines were defined using antisera and monoclonal antibodies specific for private antigenic determinants controlled by known H-2 alleles and by antisera produced using the new t lines as donors. The tTuw haplotypes fall into four groups according to the H-2 haplotype associated with them. Haplotypes tTuw10 through tTuw18 are associated with H-2W30, previously found to be linked with haplotypes of the tw1 group. Haplotypes tTuw1 through tTuw6 are associated with a new H-2 haplotype, H-2w36, characterized by the determinant H-2.107. Haplotypes tTuw7 through tTuw9 are associated with another new H-2 haplotype, H-2w37, characterized by determinants H-2.108 and H-2.111. And finally, haplotypes tTuw19 and tTuw20 are associated with yet another new H-2 haplotype, H-2w38, characterized by determinants H-2.33 and H-2.109. These findings suggest that the t polymorphism might be more extensive and more intricate than it was previously thought to be and that at least some of the t-associated H-2 haplotypes, and probably also the t haplotypes themselves, are related to one another in their origin.