Programmed contraction of CD8+ T cells after infection
Programmed contraction of CD8+ T cells after infection
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DOI：
10.1038/ni804
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发表时间：
2002-07-01
影响因子：
30.5
通讯作者：
Harty, JT
中科院分区：
文献类型：
--
作者：
Badovinac, VP;Porter, BB;Harty, JT
感染的程度和病原体清除的速度被认为决定了抗原特异性CD8(+)T细胞扩张的幅度和随后收缩到稳定数量的记忆细胞的程度。我们发现，单核细胞增多性李斯特菌感染后CD8(+)T细胞的增殖主要取决于初始感染剂量或所显示的抗原量，还受病原体清除率的影响。然而，单核细胞增多性李氏杆菌和淋巴细胞性脉络膜脑膜炎病毒感染后CD8(+)T细胞收缩的开始和动力学与病毒扩增的大小、感染的剂量和持续时间或所显示的抗原量无关。因此，抗原特异性CD8(+)T细胞稳态的主要特征，包括免疫反应的收缩阶段，可能在感染后早期编程。
The extent of infection and rate of pathogen clearance are thought to determine both the magnitude of antigen-specific CD8(+) T cell expansion and the ensuing contraction to a stable number of memory cells. We show that CD8(+) T cell expansion after Listeria monocytogenes infection was primarily dependent on the initial infection dose or amount of antigen displayed, and was also influenced by the rate of pathogen clearance. However, the onset and kinetics of CD8(+) T cell contraction after L. monocytogenes and lymphocytic choriomeningitis virus infections were independent of the magnitude of expansion, dose and duration of infection or amount of antigen displayed. Thus, major features of antigen-specific CD8(+) T cell homeostasis, including the contraction phase of an immune response, may be programmed early after infection.