Body weight gain in rats consuming sweetened liquids. Effects of caffeine and diet composition.
Body weight gain in rats consuming sweetened liquids. Effects of caffeine and diet composition.
复制标题
食用加糖液体的老鼠体重增加。
DOI：
10.1016/j.appet.2010.08.021
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发表时间：
2010
期刊：
影响因子：
5.4
通讯作者：
Davidson,TL
中科院分区：
文献类型：
--
作者：
Swithers,SusanE;Martin,AshleyA;Clark,KielyM;Laboy,AlyciaF;Davidson,TL
先前的研究表明，高强度甜味剂可以刺激老鼠体重增加。目前的研究调查了咖啡因（一种通常添加到人类饮用的饮料中的兴奋剂）是否会影响大鼠对糖精或葡萄糖甜味溶液的摄入或体重增加，以及维持饮食的性质是否会影响咖啡因的作用。在两个实验中，大鼠分别服用葡萄糖或糖精溶液，其中含有0.125mg/g咖啡因或不含咖啡因。大鼠在低脂饮食（实验1）和高糖、高脂肪、高热量饮食（实验2）中摄入的咖啡因明显多于不含咖啡因的溶液。在两个实验中，摄入糖精导致体重增加。咖啡因在实验1（低脂饮食）中逆转了这种效应，但在实验2（甜的高脂肪饮食）中没有。这一发现扩展了人们对高强度甜味剂的摄入会导致能量失调的已知情况。
Previous studies show that high-intensity sweeteners can stimulate weight gain in rats. The present studies examined whether caffeine, a stimulant commonly added to beverages consumed by humans, influences intake of saccharin- or glucose-sweetened solutions or body weight gain in rats and whether the nature of the maintenance diet influences the effects of caffeine. In two experiments, rats received glucose or saccharin solution mixed with 0.125mg/g caffeine or no caffeine. Rats consumed significantly more caffeinated than noncaffeinated solutions when they were maintained on a low-fat chow diet (Experiment 1) and when maintained on a sweet, high-fat, high calorie chow diet (Experiment 2). Consumption of saccharin resulted in higher body weight gain in both experiments. Caffeine reversed this effect in Experiment 1 (low-fat diet) but not Experiment 2 (sweet, high-fat diet). The findings extend what is known about the conditions under which consumption of high intensity sweeteners promote energy dysregulation.