In vitro degradation behavior and biocompatibility of Mg-Nd-Zn-Zr alloy by hydrofluoric acid treatment
In vitro degradation behavior and biocompatibility of Mg-Nd-Zn-Zr alloy by hydrofluoric acid treatment
复制标题
氢氟酸处理Mg-Nd-Zn-Zr合金的体外降解行为及生物相容性
DOI：
10.1016/j.msec.2012.08.036
复制
发表时间：
2013-01-01
影响因子：
7.9
通讯作者：
Ding, Wenjiang
中科院分区：
文献类型：
--
作者：
Mao, Lin;Yuan, Guangyin;Ding, Wenjiang
在这篇论文中。研究了氢氟化镁化学转化膜包覆的镁-钕-锌-锆合金(简称JDBM)作为一种潜在的可生物降解心血管支架材料。微观结构。考察了其体外降解性和生物相容性。场发射扫描电子显微镜(FE-SEM)和X射线光电子能谱(XPS)分析表明，在JDBM表面形成了致密的MgF2薄膜。在人工等离子体中的腐蚀速率从0.337 mm·y(-1)降至0.253 mm·y(-1)，电化学测试表明，由于在基材表面形成了保护性的MgF_2膜，JDBM合金的耐蚀性能得到了明显的提高。经HF处理后，JDBM的溶血率由52.0%降至10.1%，细胞毒性达到细胞应用要求。此外，JDBM和MgF2膜具有良好的抗血小板粘附性，这是一种非常有利的植入材料与血液直接接触的性能。(C)2012爱思唯尔B.V.保留所有权利。
In this paper. Mg-Nd-Zn-Zr alloy (denoted as JDBM) coated with hydrofluoric add (HF) chemical conversion film (MgF2) was researched as a potential biodegradable cardiovascular stent material. The microstructures. in vitro degradation and biocompatibility were investigated. The field emission scanning electron microscopy (FE-SEM) and X-ray photoelectron spectroscopy (XPS) showed that a compact MgF2 film was formed on the surface of JDBM. The corrosion rate decreased in artificial plasma from 0.337 to 0.253 mm.y(-1) and the electrochemical measurement demonstrated that the corrosion resistance of JDBM alloy could be obviously improved due to the protective MgF2 film on the surface of the substrate. Meanwhile, the hemolysis ratio of JDBM decreased from 52.0% to 10.1% and the cytotoxicity met the requirement of cellular application after HF treatment. In addition, JDBM and MgF2 film showed good anti-platelet adhesion, which is a very favorable property for implant material in contact with blood directly. (C) 2012 Elsevier B.V. All rights reserved.