The roles of ASK family proteins in stress responses and diseases.
The roles of ASK family proteins in stress responses and diseases.
复制标题
问家族蛋白在压力反应和疾病中的作用。
DOI：
10.1186/1478-811x-7-9
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发表时间：
2009-04-24
期刊：
影响因子：
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通讯作者：
Ichijo H
中科院分区：
文献类型：
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作者：
Hattori K;Naguro I;Runchel C;Ichijo H
凋亡信号调节激酶1（Apoptosis signal-regulating kinase 1，ASK 1）是丝裂原活化蛋白激酶家族的成员，其响应于多种应激如氧化应激、内质网应激和钙内流而激活c-Jun N-末端激酶和p38。在过去的十年中，已经阐明了ASK 1的各种调节机制，包括其氧化应激依赖性激活。近年来，研究发现ASK家族蛋白在癌症、心血管疾病和神经退行性疾病中发挥着重要作用。本文就ASK家族蛋白的研究进展及其在多种疾病中的意义作一综述。
Apoptosis signal-regulating kinase 1 (ASK1) is a member of the mitogen-activated protein kinase kinase kinase family, which activates c-Jun N-terminal kinase and p38 in response to a diverse array of stresses such as oxidative stress, endoplasmic reticulum stress and calcium influx. In the past decade, various regulatory mechanisms of ASK1 have been elucidated, including its oxidative stress-dependent activation. Recently, it has emerged that ASK family proteins play key roles in cancer, cardiovascular diseases and neurodegenerative diseases. In this review, we summarize the recent findings on ASK family proteins and their implications in various diseases.