IDENTIFICATION OF AN AMPLIFIED, HIGHLY EXPRESSED GENE IN A HUMAN GLIOMA
IDENTIFICATION OF AN AMPLIFIED, HIGHLY EXPRESSED GENE IN A HUMAN GLIOMA
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DOI：
10.1126/science.3563490
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发表时间：
1987-04-03
期刊：
影响因子：
56.9
通讯作者：
VOGELSTEIN, B
中科院分区：
文献类型：
--
作者：
KINZLER, KW;BIGNER, SH;VOGELSTEIN, B
一种名为gli的基因在恶性胶质瘤中被扩增了50倍以上。该基因在原肿瘤及其衍生细胞系中高水平表达，定位于12号染色体位置(q13~q14.3)。Gli基因是一组精选的细胞基因中的一员，这些基因在人类原发肿瘤中发生了基因改变。
A gene, termed gli, was identified that is amplified more than 50-fold in a malignant glioma. The gene is expressed at high levels in the original tumor and its derived cell line and is located at chromosome 12 position (q13 to q14.3). The gli gene is a member of a select group of cellular genes that are genetically altered in primary human tumors.