The application of visceral adiposity index in identifying type 2 diabetes risks based on a prospective cohort in China.
The application of visceral adiposity index in identifying type 2 diabetes risks based on a prospective cohort in China.
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DOI：
10.1186/1476-511x-13-108
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发表时间：
2014-07-08
影响因子：
4.5
通讯作者：
Hu XS
中科院分区：
文献类型：
--
作者：
Chen C;Xu Y;Guo ZR;Yang J;Wu M;Hu XS
内脏脂肪指数(VAI)是近年来提出的一种新的测量内脏脂肪的性别指标。我们评估了体重指数在中国人中识别糖尿病风险的有效性，并比较了体重指数与其他体脂指标如腰围、体重指数和腰围/身高比的预测能力。受试者(n = 3,461)是从江苏省正在进行的队列研究中国中招募的。用COX比例风险回归模型估计糖尿病风险与不同体脂指数之间的危险比(HR)和相应的95%可信区间(CI)。应用受试者工作特征(ROC)曲线和曲线下面积(AUC)比较VAI、WC、WHtR和BMI对糖尿病风险的识别能力。随访期间共发生新发糖尿病病例160例，发病率为4.6%。VAI与血压、空腹血糖、甘油三酯、WC、BMI和WHtR呈显著正相关。此外，观察到VAI值的增加与糖尿病风险的增加相关，并且呈正的剂量-反应趋势(趋势 <； 0.001)。与VAI最低的个体相比，VAI最高的个体患糖尿病的风险是2.55倍(95%CI：1.58-4.11)。最大的AUC是VAI，其次是WC、WHtR和BMI。血管紧张素转换酶与糖尿病风险呈正相关。与其他体脂测量指标相比，VAI是一种更好、更方便的内脏脂肪测量替代指标，可用于在大规模流行病学研究中识别糖尿病风险。
Visceral adiposity index (VAI), a novel sex-specific index for visceral fat measurement, has been proposed recently. We evaluate the efficacy of VAI in identifying diabetes risk in Chinese people, and compare the predictive ability between VAI and other body fatness indices, i.e., waist circumference (WC), body mass index (BMI) and waist- to- height ratio (WHtR). Participants (n = 3,461) were recruited from an ongoing cohort study in Jiangsu Province, China. Hazard ratio (HR) and corresponding 95% confidence interval (CI) between diabetes risk and different body fatness indices were evaluated by Cox proportional hazard regression model. Receiver operating characteristic (ROC) curve and area under curve (AUC) were applied to compare the ability of identifying diabetes risk between VAI, WC, WHtR and BMI. A total number of 160 new diabetic cases occurred during the follow-up, with an incidence of 4.6%. Significant positive associations were observed for VAI with blood pressure, fasting plasma glucose, triglyceride, WC, BMI and WHtR. Moreover, increased VAI was observed to be associated with higher diabetes risk with a positive dose–response trend (p for trend < 0.001). As compared to individuals with the lowest VAI, those who had the highest VAI were at 2.55-fold risk of diabetes (95% CI: 1.58-4.11). The largest AUC was observed for VAI, following by WC, WHtR and BMI. VAI is positively associated with the risk of diabetes. Compared to other indices for body fatness measurements, VAI is a better and convenience surrogate marker for visceral adipose measurement and could be used in identifying the risk of diabetes in large-scale epidemiologic studies.