Molecular epidemiology of antibiotic resistance in salmonella from animals and human beings in the United States.
Molecular epidemiology of antibiotic resistance in salmonella from animals and human beings in the United States.
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美国动物和人类沙门氏菌抗生素耐药性的分子流行病学。
DOI：
10.1056/nejm198207013070101
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Morse,EV
中科院分区：
文献类型：
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作者：
O'Brien,TF;Hopkins,JD;Gilleece,ES;Medeiros,AA;Kent,RL;Blackburn,BO;Holmes,MB;Reardon,JP;Vergeront,JM;Schell,WL;Christenson,E;Bissett,ML;Morse,EV
我们从美国的参考实验室收集了血清型沙门氏菌分离株，测试了它们对抗生素的敏感性，并从对三种血清型的不同抗生素组合具有耐药性的分离株中提取了质粒。限制性内切酶酶切表明，在这三组中，来自动物和人类分离的质粒分子往往相同或几乎相同。一种血清型-质粒组合似乎在20个州的牛中流行，并在两个州感染了26人。人类病例除了具有共同的质粒外没有明显的相关性，它们似乎在时间上聚集在一起，但在地理上分散，就像以前由食品传播的疫情中的病例一样。这些发现表明，耐药质粒可能在动物和人类细菌之间广泛共享，而且在英国观察到的沙门氏菌多重耐药菌株在动物和人类之间的传播，可能在美国由于缺乏类似的监测而未被发现。（中华医学杂志。1982;37:1 - 6）
We collected serotyped isolates of salmonella from reference laboratories in the United States, tested their susceptibility to antibiotics, and extracted plasmids from isolates that were resistant to a different combination of antibiotics from each of three serotypes. Restriction-endonuclease digestion showed that within each of the three groups, plasmid molecules from animal and human isolates were often identical or nearly identical.One serotype-plasmid combination appeared to be endemic in cattle in 20 states and infected 26 persons in two states. The human cases, which were not recognizably related except for their common plasmids, appeared to be clustered in time but geographically dispersed, like cases in previous outbreaks spread by food products. These findings suggest that resistance plasmids may be extensively shared between animal and human bacteria, and that spread of multiresistant strains of salmonella among animals and human beings, as observed in Britain, may have been undetected in the United States for lack of comparable surveillance. (N Engl J Med. 1982; 307:1–6.)