Triglyceride/glucose index is a reliable alternative marker for insulin resistance in South American overweight and obese children and adolescents
Triglyceride/glucose index is a reliable alternative marker for insulin resistance in South American overweight and obese children and adolescents
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DOI：
10.1515/jpem-2019-0037
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发表时间：
2019-10-01
影响因子：
1.4
通讯作者：
Nardo Junior, Nelson
中科院分区：
文献类型：
--
作者：
Locateli, Joao Carlos;Lopes, Wendell Arthur;Nardo Junior, Nelson
背景：本研究的目的是探讨甘油三酯/葡萄糖指数（TyG 指数）与胰岛素抵抗稳态模型评估（HOMA-IR）之间的相关性。此外，我们还比较了 TyG 指数和甘油三酯/高密度脂蛋白胆固醇 (TG/HDL-c) 指数以及这两个指数的组合（TyG 指数加 TG/HDL-c）预测南美超重和肥胖儿童和青少年胰岛素抵抗 (IR) 的能力。 方法：对 345 名 10-18 岁超重青少年（男女）进行了一项横断面研究。 TyG 指数计算为 Ln（空腹甘油三酯 [mg/dL] x 空腹血糖 [mg/dL]）/2，而 TG/HDL-c 指数则通过 TG (mg/dL) 除以 HDL-c (mg/dL) 计算。 HOMA-IR的计算公式为：空腹胰岛素(FI)(U/mL)×空腹血糖(mmol/L)/22.5。用于确定 IR 存在的分界点是 HOMA-IR >= 3.16。 结果：TyG 指数与 HOMA-IR 呈正相关。 TyG 指数的受试者工作特征（ROC）曲线下面积为 0.74，表明良好的敏感性（75.7%）和特异性（67.4%）。此外，为该人群的 IR 预测建立了 >4.44 的 TyG 指数截止点。结论：TyG 指数是南美超重儿童和青少年 IR 的简单且经济有效的替代标记。此外，由于其良好的可访问性，它可以用于大型流行病学研究。
Background: The aim of the present study was to investigate the correlation between the triglyceride/glucose index (TyG index) and homeostasis model assessment of insulin resistance (HOMA-IR). Additionally, we compared the ability of the TyG index and triglycerides/high-density lipoprotein cholesterol (TG/HDL-c) index and the combination of these two indices (TyG index plus TG/HDL-c) to predict insulin resistance (IR) in South American overweight and obese children and adolescents.Methods: A cross-sectional study was carried out in 345 overweight adolescents aged 10-18 years, from both the sexes. The TyG index was calculated as Ln (fasting triglycerides [mg/dL] x fasting glucose [mg/dL])/2, while the TG/HDL-c index was calculated by the division of TG (mg/dL) by HDL-c (mg/dL). HOMA-IR was calculated with the formula: fasting insulin (FI) (U/mL)x fasting glucose (mmol/L)/22.5. The cut-off point used to determine the presence of IR was HOMA-IR >= 3.16.Results: The TyG index showed a positive correlation with HOMA-IR. The area under the receiver operating characteristic (ROC) curve of the TyG index was 0.74, indicating good sensitivity (75.7%) and specificity (67.4%). Furthermore, the TyG index cut-off point of >4.44 was established for IR prediction in this population.Conclusions: The TyG index is a simple and cost-effective surrogate marker of IR in South American overweight children and adolescents. Moreover, due to its good accessibility, it can be used in large epidemiological studies.