SEROTONIN-CONTAINING AXON TERMINALS IN THE HYPOGLOSSAL NUCLEUS OF THE RAT - AN IMMUNO-ELECTRONMICROSCOPIC STUDY
SEROTONIN-CONTAINING AXON TERMINALS IN THE HYPOGLOSSAL NUCLEUS OF THE RAT - AN IMMUNO-ELECTRONMICROSCOPIC STUDY
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DOI：
10.1016/0361-9230(89)90154-8
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发表时间：
1989-09-01
影响因子：
3.8
通讯作者：
CHRONISTER, RB
中科院分区：
文献类型：
--
作者：
ALDES, LD;MARCO, LA;CHRONISTER, RB
用免疫细胞化学方法研究了大鼠舌下核(XII)内含5-羟色胺的轴突终末的形态和分布。5-羟色胺阳性分布遍及XII的所有区域，包括无髓鞘轴突、静脉曲张和轴突终末。大多数标记的轮廓(68.1%)是非突触无髓轴突和静脉曲张，而以树突和胞体为终点的突触轮廓较少(28.7%)。大多数标记轴突终末(76.9%)终止于中小型树突。大多数轴突终末含有小的圆形无颗粒小泡(20-55微米)和几个大的(60-100微米)致密的核心小泡，并与明显的不对称突触后特化有关。相反，标记的轴突终末少于树突终末(23.0%)。轴体终末通常含有小的、圆形的、无颗粒的和大的致密的核心小泡，并与对称性或无突触后特化有关。这些结果为阐明5-羟色胺在舌控制中的功能作用提供了结构底物。
The morphology and distribution of serotonin-containing axon terminals in the rat hypoglossal nucleus (XII) was investigated immunocytochemically at the electron microscopic level. Serotonin-positive profiles were found throughout all regions of XII and included unmyelinated axons, varicosities and axon terminals. Most labeled profiles (68.1%) were nonsynaptic unmyelinated axons and varicosites, while synaptic profiles, ending on dendrites and somata, were seen less frequently (28.7%). The majority of labeled axon terminals (76.9%) ended on small-to-medium-sized dendrites. Most axodendritic terminals contained small, round agranular vesicles (20-55 .mu.m), several large (60-100 .mu.m) dense core vesicles, and were associated with a pronounced asymmetric postsynaptic specialization. By contrast, labeled axosomatic terminals were seen less often than those ending on dendrites (23.0%). Axosomatic terminals typically contained small, round, agranular and large dense core vesicles and were associated with a symmetric or no postsynaptic specialization. These results provide the structural substrates for elucidating the functional role of serotonin in tongue control.