Calciotrophic hormone levels and calcium absorption during pregnancy in rats.
Calciotrophic hormone levels and calcium absorption during pregnancy in rats.
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大鼠妊娠期间促钙激素水平和钙吸收。
DOI：
10.1152/ajpendo.1989.257.1.e118
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Miller,SC
中科院分区：
文献类型：
--
作者：
Quan-Sheng,D;Miller,SC
哺乳动物的母体骨骼在怀孕期间储存钙，可能是为了怀孕后期胎儿骨骼矿化和哺乳期间的产奶量。测定妊娠不同阶段大鼠肠道钙吸收与肥厚与血浆总钙、离子钙、25-羟基维生素D3 [25(OH)D]、1,25-二羟基维生素D3 [1,25(OH)2D]、甲状旁腺激素（PTH）水平的相互关系。妊娠中期及胎儿骨骼矿化前，血浆离子钙水平、离体十二指肠组织钙吸收量、原位十二指肠钙吸收量和十二指肠湿重均升高，25(OH)D降低。在妊娠后期，胎儿骨骼矿化期间，1,25(OH)2D和PTH水平也显著升高，血清总钙水平下降。这些数据表明，在怀孕中期，胎儿骨骼矿化之前，母体矿物质稳态的变化伴随着骨骼代谢的已知变化。矿物质代谢的一些早期变化可能独立于维生素D和甲状旁腺激素内分泌系统发生。
The mammalian maternal skeleton stores Ca during pregnancy perhaps for fetal skeletal mineralization in late pregnancy and milk production during lactation. The interrelationships between intestinal Ca absorption and hypertrophy and plasma levels of total Ca, ionized Ca, 25-hydroxyvitamin D3 [25(OH)D], 1,25-dihydroxyvitamin D3 [1,25(OH)2D], and parathyroid hormone (PTH) were determined at different stages of pregnancy in rats. By midpregnancy and before fetal skeletal mineralization, plasma ionized Ca levels, Ca absorption by duodenal tissue in vitro, Ca absorption by the duodenum in situ, and duodenal wet weight were increased and 25(OH)D was decreased. Later in pregnancy, during fetal skeletal mineralization, 1,25(OH)2D and PTH levels were also substantially increased and total serum Ca levels decreased. These data demonstrate changes by midpregnancy, before fetal skeletal mineralization, in maternal mineral homeostasis concomitant with known changes in skeletal metabolism. Some of the early changes in mineral metabolism may occur independent of the vitamin D and PTH endocrine system.