Use of 5-FU plus hyperbaric oxygen for treating malignant tumors: evaluation of antitumor effect and measurement of 5-FU in individual organs
Use of 5-FU plus hyperbaric oxygen for treating malignant tumors: evaluation of antitumor effect and measurement of 5-FU in individual organs
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DOI：
10.1007/s002800000190
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发表时间：
2001-01-01
影响因子：
3
通讯作者：
Nakajima, N
中科院分区：
文献类型：
--
作者：
Takiguchi, N;Saito, N;Nakajima, N
目的：高压氧（HBO）已被证明可以增加肿瘤的放射敏感性。一些报告表明，它也增加了对烷化剂的敏感性，但其他报告表明，它可能会加速血管生成和肿瘤生长。为了阐明这些问题，我们研究了HBO和5-氟尿嘧啶（5-FU）单独或联合对小鼠肉瘤180移植物的影响。研究方法：我们以0.75 mg/只小鼠的剂量每周6次给予5-FU，并以2 atm绝对压力每周6次给予HBO 90 min，共17次。在联合治疗中，在注射5-FU后立即给予HBO。结果如下：在治疗期间，未经治疗的对照组肿瘤直径增加了277.8%，HBO单药治疗组增加了244.1%，5-FU单药治疗组增加了182.7%，联合治疗组增加了138.5%。伴随HBO增加了5-FU在受体动物的肿瘤、肝脏和肾脏中的蓄积，但在脑中没有。结论：根据上述结果，我们得出结论，合并HBO增强5-FU的效果。
Purpose: Hyperbaric oxygen (HBO) has been shown to increase tumor radiosensitivity. Several reports indicate that it also increases sensitivity to alkylating agents, but other reports suggest that it may speed angiogenesis and tumor growth. To throw light on these questions, we investigated the effects of HBO and 5-fluorouracil (5-FU), individually and in combination, on Sarcoma 180 implants in mice. Methods: We administered 5-FU at a dose of 0.75 mg/mouse six times per week and HBO at 2 atm absolute pressure for 90 min six times per week, both 17 times in total. In combination treatment, HBO was administered immediately after 5-FU injection. Results: Over the treatment period, tumor diameter increased 277.8% in the untreated control group, 244.1% in the group receiving HBO monotherapy, 182.7% in the group receiving 5-FU monotherapy, and 138.5% in the group receiving combination therapy. Concomitant HBO increased accumulation of 5-FU in the tumors, liver, and kidneys, but not in the brain, of recipient animals. Conclusions: Based on the above results, we conclude that concomitant HBO enhances the effects of 5-FU.