Microstructural abnormality in white matter, regulatory T lymphocytes, and depressive symptoms after stroke.
Microstructural abnormality in white matter, regulatory T lymphocytes, and depressive symptoms after stroke.
复制标题
白质微观结构异常、调节性 T 淋巴细胞和中风后抑郁症状。
DOI：
10.1002/gps.4235
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发表时间：
2014
期刊：
影响因子：
2
通讯作者：
Nagatsuka K.
中科院分区：
文献类型：
--
作者：
Yasuno F;Taguchi A;Yamamoto A;Kajimoto K;Kazui H;Kudo T;Kikuchi-Taura A;Sekiyama A;Kishimoto T;Iida H;Nagatsuka K.
几项流行病学研究发现，高学历人群中阿尔茨海默病的发病率较低，但教育对疾病的保护机制仍不清楚。我们的目的是调查教育和11 C-标记的匹兹堡化合物B（PI B）摄取与正电子发射断层扫描参与者与正常的认知能力之间的关联。MethodsWe performed 11 C-标记的PI B正电子发射断层扫描和神经心理测试在30个认知正常的老年参与者。在参与者中，16人的受教育时间少于12年（低教育组），14人超过13年（高教育组）。淀粉样蛋白-β沉积定量结合电位（BPND）在几个大脑区域，并与不同的教育levels.ResultsWe组之间进行了比较，发现显着较高的皮质PIB-BPND在认知正常的参与者，教育程度低，与那些高教育。低学历组的大脑区域均未显示出显著较低的BPND值。这一发现不受包括可能的混杂变量（如年龄、性别和一般智力）的影响。我们的研究结果表明，在受过高等教育，认知正常，participants.ConclusionsOur的研究结果导致的建议，即早期教育与阿尔茨海默病的病理学有负相关。这个提议并不反对大脑储备假说。受教育程度较高的人可能在临床前阶段之前对淀粉样蛋白-β沉积有更大的抑制作用。同时，他们有更大的储备能力，痴呆症需要更大的病理变化。版权所有© 2014约翰威利父子有限公司.
ObjectiveSeveral epidemiological studies have found a lower incidence of Alzheimer's disease in highly educated populations, but the protective mechanism of education against the disease is still unclear. Our objective was to investigate the association between education and11C‐labeled Pittsburgh Compound B (PIB) uptake with positron emission tomography in participants with normal cognitive ability.MethodsWe performed11C‐labeled PIB positron emission tomography and neuropsychological testing in 30 cognitively normal older participants. Of the participants, 16 had a period of education less than 12 years (low‐education group) and 14 had more than 13 years (high‐education group). Amyloid‐β deposition was quantified by binding potential (BPND) in several brain regions and was compared between the groups with different education levels.ResultsWe found significantly higher cortical PIB‐BPNDin the cognitively normal participants with low education compared with the ones with high education. None of the brain regions in low‐education group showed significantly lower BPNDvalues. This finding was not affected by the inclusion of possible confounding variables such as age, sex, and general intelligence. Our findings indicated a reduced amyloid pathology in highly educated, cognitively normal, participants.ConclusionsOur findings lead to the proposal that early‐life education has a negative association with Alzheimer's disease pathology. This proposal is not in opposition to the brain reserve hypothesis. People with more education might be prone to a greater inhibitory effect against amyloid‐β deposition before the preclinical stage. At the same time, they have a greater reserve capacity, and greater pathological changes are required for dementia to manifest. Copyright © 2014 John Wiley & Sons, Ltd.