Early Life Trauma Has Lifelong Consequences for Sleep And Behavior
Early Life Trauma Has Lifelong Consequences for Sleep And Behavior
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DOI：
10.1038/s41598-019-53241-y
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发表时间：
2019-11-13
影响因子：
4.6
通讯作者：
Wilson, Donald A.
中科院分区：
文献类型：
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作者：
Lewin, Monica;Lopachin, Jenna;Wilson, Donald A.
睡眠质量因人而异，特别是在正常衰老期间，睡眠受损会导致认知和情绪调节的缺陷。睡眠也会受到各种不良事件的影响，包括童年的逆境。在这里，我们研究了早期生活中的不良事件如何影响晚年的睡眠结构和生理，使用动物模型来测试早期生活中的逆境和整个生命周期的睡眠质量之间的关系。从出生后第8-12天，将大鼠幼崽暴露于逆境-稀缺模型，其中用于筑巢的垫料不足会诱导母体虐待幼崽。多导睡眠图和睡眠生理进行了评估断奶，早期成人和老年人。早期生活逆境导致睡眠和行为的年龄依赖性中断，包括终身纺锤体减少和晚年NREM睡眠片段化。鉴于睡眠在认知和情感功能中的重要性，这些结果突出了一个重要因素，即在整个生命周期中驱动睡眠，认知和情感的变化，这表明睡眠问题的年龄和创伤信息治疗。
Sleep quality varies widely across individuals, especially during normal aging, with impaired sleep contributing to deficits in cognition and emotional regulation. Sleep can also be impacted by a variety of adverse events, including childhood adversity. Here we examined how early life adverse events impacted later life sleep structure and physiology using an animal model to test the relationship between early life adversity and sleep quality across the life span. Rat pups were exposed to an Adversity-Scarcity model from postnatal day 8-12, where insufficient bedding for nest building induces maternal maltreatment of pups. Polysomnography and sleep physiology were assessed in weaning, early adult and older adults. Early life adversity induced age-dependent disruptions in sleep and behavior, including lifelong spindle decreases and later life NREM sleep fragmentation. Given the importance of sleep in cognitive and emotional functions, these results highlight an important factor driving variation in sleep, cognition and emotion throughout the lifespan that suggest age-appropriate and trauma informed treatment of sleep problems.