Epigenetics and environmental chemicals.
Epigenetics and environmental chemicals.
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DOI：
10.1097/mop.0b013e32832925cc
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发表时间：
2009-04
影响因子：
3.6
通讯作者：
Bollati V
中科院分区：
文献类型：
--
作者：
Baccarelli A;Bollati V
表观遗传学研究在不改变DNA序列的情况下发生的基因表达的可遗传变化。一些表观遗传机制，包括DNA甲基化、组蛋白修饰和microRNA(MiRNA)表达，可以在外源影响下改变基因组功能。在这里，我们回顾了目前的证据表明，表观遗传改变介导了环境化学品的毒性。体外、动物和人类研究已经确定了几类改变表观遗传标记的环境化学品，包括金属(镉、砷、镍、铬、甲基汞)、过氧化物体增殖剂(三氯乙烯、二氯乙酸、三氯乙酸)、空气污染物(颗粒物、黑碳、苯)和内分泌/生殖毒物(己烯雌酚、双酚A、持久性有机污染物、二恶英)。到目前为止，大多数研究都集中在DNA甲基化上，而只有少数研究与组蛋白修饰和miRNA有关的环境化学物质。对于几次暴露，已经证明化学品可以改变表观遗传标记，在所关注的疾病患者或患病组织中也可以发现相同或类似的表观遗传改变。未来需要进行前瞻性研究，以确定暴露的受试者是否会随着时间的推移发生表观遗传改变，进而增加疾病的风险。此外，还需要进一步的研究来确定环境表观遗传变化是否会跨代传播。
Epigenetics investigates heritable changes in gene expression occurring without changes in DNA sequence. Several epigenetic mechanisms, including DNA methylation, histone modifications, and microRNA (miRNA) expression, can change genome function under exogenous influence. Here, we review current evidence indicating that epigenetic alterations mediate toxicity from environmental chemicals. In-vitro, animal, and human investigations have identified several classes of environmental chemicals that modify epigenetic marks, including metals (cadmium, arsenic, nickel, chromium, methylmercury), peroxisome proliferators (trichloroethylene, dichloroacetic acid, trichloroacetic acid), air pollutants (particulate matter, black carbon, benzene), and endocrine-disrupting/reproductive toxicants (diethylstilbestrol, bisphenol A, persistent organic pollutants, dioxin). Most studies conducted so far have been centered on DNA methylation, whereas only a few investigations have studied environmental chemicals in relation to histone modications and miRNA. For several exposures, it has been proved that chemicals can alter epigenetic marks and that the same or similar epigenetic alterations can be found in patients with the disease of concern or in diseased tissues. Future prospective investigations are needed to determine whether exposed subjects develop epigenetic alterations over time and, in turn, which such alterations increase the risk of disease. Also, further research is needed to determine whether environmental epigenetic changes are transmitted transgenerationally.
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DOI：
10.1002/tera.1420450612
发表时间：
1992-06-01
期刊：
TERATOLOGY
影响因子：
--
作者：
HALES, BF;CROSMAN, K;ROBAIRE, B
通讯作者：
ROBAIRE, B
影响因子：
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作者：
Bollati, Valentina;Baccarelli, Andrea;Yang, Allen S.
通讯作者：
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DOI：
10.1016/j.mrfmmm.2003.11.006
发表时间：
2004-02-26
影响因子：
2.3
作者：
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通讯作者：
Hei, TK
影响因子：
3.6
作者：
Chuang, Jody C.;Jones, Peter A.
通讯作者：
Jones, Peter A.
影响因子：
3.5
作者：
Baccarelli, A;Pesatori, AC;Landi, MT
通讯作者：
Landi, MT