The effect of Heweijiangni-decoction on esophageal morphology in a rat model of OVA-induced visceral hypersensitivity followed by acid exposure
The effect of Heweijiangni-decoction on esophageal morphology in a rat model of OVA-induced visceral hypersensitivity followed by acid exposure
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DOI：
10.14715/cmb/2019.65.5.12
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发表时间：
2019-01-01
影响因子：
1.6
通讯作者：
Li, Jun-xiang
中科院分区：
文献类型：
--
作者：
Jia, Bo-yi;Xie, Chun-e;Li, Jun-xiang
合胃降泥汤是临床治疗非糜烂性反流病的有效中药方剂。食道过敏和胃酸是导致此病的原因。然而，确切的潜在作用机制仍不清楚。在这项研究中，我们观察了HWJND对卵清蛋白（OVA）诱导的内脏超敏大鼠酸暴露模型食管形态的影响。食管形态学通过测量细胞间隙扩张（DIS）、桥粒断裂和线粒体断裂程度来评估。与模型组比较，低、中、高剂量HWJND可减轻食管上皮DIS和桥粒破坏(P
Heweijiangni decoction (HWJND) is an effective traditional Chinese medicine prescription in clinical treatment of nonerosive reflux disease (NERD). Esophageal hypersensitivity and acid contribute to the disease. However, the exact underlying mechanism of action remains unclear. In this study, we observed the effect of HWJND on esophageal morphology in a rat model of ovalbumin (OVA)-induced visceral hypersensitivity followed by acid exposure. Esophageal morphology was assessed by measuring the extent of dilated intercellular spaces (DIS), desmosome disruption, and mitochondrial fragmentation. HWJND in low, moderate, and high doses relieved DIS and desmosome disruption in esophageal epithelium compared with model group (P