Acid-catalyzed tandem reaction for the synthesis of pyridine derivatives via C=C/C(sp(3))-N bond cleavage of enones and primary amines
Acid-catalyzed tandem reaction for the synthesis of pyridine derivatives via C=C/C(sp(3))-N bond cleavage of enones and primary amines
复制标题
酸催化串联反应通过烯酮和伯胺的 C=C/C(sp(3))-N 键断裂合成吡啶衍生物
DOI：
10.1039/c7ra00780a
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发表时间：
2017
期刊：
影响因子：
3.9
通讯作者：
Pan Ying-Ming
中科院分区：
文献类型：
--
作者：
Mao Zhong-Yuan;Liao Xiao-Yun;Wang Heng-Shan;Wang Chun-Gu;Huang Ke-Bin;Pan Ying-Ming
在不使用任何金属试剂或额外氧化剂的条件下，开发了一种一锅酸催化串联反应。该反应涉及通过“掩蔽的”反向Aldol反应的烯酮的C1 C键裂解，和伯胺的C（sp3）-N键裂解，以提供用于以高产率组装具有优异官能团耐受性的吡啶衍生物的氮源。
A one-pot acid-catalyzed tandem reaction has been developed without any metallic reagents or extra oxidants. This reaction involves a C] C bond cleavage of enones via a “masked” reverse Aldol reaction, and C (sp3)–N bond cleavage of primary amines to provide nitrogen sources for the assembly of pyridine derivatives in high yields with excellent functional group tolerance.