Quantitative morphology of the caudate and putamen in patients with cocaine dependence
Quantitative morphology of the caudate and putamen in patients with cocaine dependence
复制标题
DOI：
10.1176/appi.ajp.158.3.486
复制
发表时间：
2001-03-01
影响因子：
17.7
通讯作者：
Krystal, JH
中科院分区：
文献类型：
--
作者：
Jacobsen, LK;Giedd, JN;Krystal, JH
目的：多巴胺能功能缺陷可能导致纹状体肥大，这与典型的抗精神病药物治疗有关。鉴于大量研究表明慢性可卡因使用与锥体外系症状和纹状体多巴胺能耗竭有关，作者寻找慢性可卡因依赖患者纹状体畸形的证据。方法：用磁共振成像技术对25例可卡因依赖者和20例健康者的尾状核、壳核和脑总容量进行定量分析。结果：可卡因依赖者尾状核和壳核体积分别增大3.40%和9.18%。结论：这些观察结果表明，与可卡因依赖相关的多巴胺能功能缺陷可能导致纹状体肥大。
Objective: Deficits in dopaminergic function may contribute to hypertrophy of striata[ structures associated with typical neuroleptic treatment, in light of a body of research that has associated chronic cocaine use with extrapyramidal symptoms and striatal dopaminergic depletion, the authors looked for evidence of striatal dysmorphology in patients with chronic cocaine dependence.Method: Caudate, putamen, and total brain volumes were quantified by means of magnetic resonance imaging in 25 cocaine-dependent and 20 healthy subjects.Results: Normalized caudate and putamen Volumes were 3.40% and 9.18% larger, respectively, in the cocaine-dependent subjects.Conclusions: These observations suggest that deficits in dopaminergic function associated with cocaine dependence may contribute to striatal hypertrophy.