Actigraphy for the Assessment of Sleep Measures in Parkinson's Disease
Actigraphy for the Assessment of Sleep Measures in Parkinson's Disease
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DOI：
10.5665/sleep.2888
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发表时间：
2013-08-01
期刊：
影响因子：
5.6
通讯作者：
Ancoli-Israel, Sonia
中科院分区：
文献类型：
--
作者：
Maglione, Jeanne E.;Liu, Lianqi;Ancoli-Israel, Sonia
目的：评估腕动记录仪对帕金森病（PD）患者夜间睡眠评估的有效性。设计：参与者同时接受多导睡眠图（PSG）和腕动记录仪的夜间睡眠评估。设置：学术睡眠研究实验室的夜间睡眠研究。参与者：61名患者（平均年龄67.74 ± 8.88岁），轻度至中度PD。睡眠测量包括总睡眠时间（TST）、睡眠效率（SE）、入睡后觉醒（WASO），和睡眠起始潜伏期（SOL）独立于来自PSG和体动记录仪的数据计算。不同的体动计评分设置compared.Results：没有单一的测试体动计评分设置是最佳的所有睡眠措施。自定义设置活动阈值为10，连续5分钟不动用于睡眠开始，产生平均TST、SE和WASO值的组合，其最接近PSG确定的平均值，TST的差异为6.05 +/- 85.67分钟，SE的差异为1.1 +/- 0.641%，WASO的差异为4.35 +/- 59.56分钟。使用这些设置，体动记录仪和PSG测量值之间存在显著但中等的相关性（对于TST，r（s）= 0.496，P < 0.001;对于SE，r（s）= 0.384，P = 0.002;对于WASO，r（s）= 0.400，P = 0.001）。疾病分期越高，TST（R-2 = 0.099，β = 0.315，P = 0.018），SE（R-2 = 0.107，β = 0.327，P = 0.014）和WASO（R-2 = 0.094，β = 0.307，P = 0.021）值，由体动记录仪和PSG得出，解释了一些变异性。使用10分钟不动的设置为睡眠开始产生的平均SOL是在1分钟内的PSG估计。然而，SOL值确定的活动记录仪和PSG没有显着相关性在任何测试setting.Conclusions：我们的研究结果表明，活动记录仪可能是有用的测量的平均TST，SE，和WASO值在轻中度帕金森病患者组。然而，个体患者之间的准确性存在显著程度的差异。强调了确定每个研究人群的最佳评分参数的重要性。
Objectives: To assess the usefulness of actigraphy for assessment of nighttime sleep measures in patients with Parkinson's disease (PD).Design: Participants underwent overnight sleep assessment simultaneously by polysomnography (PSG) and actigraphy.Setting: Overnight sleep study in academic sleep research laboratory.Participants: Sixty-one patients (mean age 67.74 +/- 8.88 y) with mild to moderate PD.Measurements: Sleep measures including total sleep time (TST), sleep efficiency (SE), wake after sleep onset (WASO), and sleep onset latency (SOL) were calculated independently from data derived from PSG and from actigraphy. Different actigraphy scoring settings were compared.Results: No single tested actigraphy scoring setting was optimal for all sleep measures. A customized setting of an activity threshold of 10, with five consecutive immobile minutes for sleep onset, yielded the combination of mean TST, SE, and WASO values that best approximated mean values determined by PSG with differences of 6.05 +/- 85.67 min for TST, 1.1 +/- 0.641% for SE, and 4.35 +/- 59.56 min for WASO. There were significant but moderate correlations between actigraphy and PSG measurements (r(s) = 0.496, P < 0.001 for TST, r(s) = 0.384, P = 0.002 for SE, and r(s) = 0.400, P = 0.001 for WASO) using these settings. Greater disease stage was associated with greater differences between TST (R-2 = 0.099, beta = 0.315, P = 0.018), SE (R-2 = 0.107, beta = 0.327, P = 0.014), and WASO (R-2 = 0.094, beta = 0.307, P = 0.021) values derived by actigraphy and PSG explaining some of the variability. Using a setting of 10 immobile min for sleep onset yielded a mean SOL that was within 1 min of that estimated by PSG. However SOL values determined by actigraphy and PSG were not significantly correlated at any tested setting.Conclusions: Our results suggest that actigraphy may be useful for measurement of mean TST, SE, and WASO values in groups of patients with mild to moderate Parkinson's disease. However, there is a significant degree of variability in accuracy among individual patients. The importance of determining optimal scoring parameters for each population studied is underscored.