Symbiotic organs shaped by distinct modes of genome evolution in cephalopods
Symbiotic organs shaped by distinct modes of genome evolution in cephalopods
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DOI：
10.1073/pnas.1817322116
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发表时间：
2019-02-19
影响因子：
11.1
通讯作者：
Nyholm, Spencer V.
中科院分区：
文献类型：
--
作者：
Belcaid, Mahdi;Casaburi, Giorgio;Nyholm, Spencer V.
微生物一直是动物进化创新的关键驱动力。要了解的过程中，影响专门的共生器官的起源，我们报告的基因组的Euprymna tuberopes，一个模式头足类动物具有丰富的特点宿主-微生物相互作用的测序和分析。我们鉴定了E.章鱼和章鱼bimaculoides，并认为这种重组有助于头足类动物的复杂性进化。为了揭示宿主-共生体相互作用的基因组特征，我们将重点放在E.观察者：光器官，其中窝藏费氏弧菌的单一培养物，和附巢腺（ANG），一种含有细菌聚生体的生殖器官。我们的研究结果表明，E。不同的物种起源于不同的进化机制。在这些微生物相关组织中表达的转录物在编码序列和周围的调控区中显示出它们自己独特的特征。与其他组织相比，光器官中含有丰富的免疫相关基因和介导光的基因，而ANG中则含有仅从E.我是说...总之，这些分析提供了证据，在一个单一的主机内共生器官的基因组进化的不同模式。
Microbes have been critical drivers of evolutionary innovation in animals. To understand the processes that influence the origin of specialized symbiotic organs, we report the sequencing and analysis of the genome of Euprymna scolopes, a model cephalopod with richly characterized host-microbe interactions. We identified large-scale genomic reorganization shared between E. scolopes and Octopus bimaculoides and posit that this reorganization has contributed to the evolution of cephalopod complexity. To reveal genomic signatures of host-symbiont interactions, we focused on two specialized organs of E. scolopes: the light organ, which harbors a monoculture of Vibrio fischeri, and the accessory nidamental gland (ANG), a reproductive organ containing a bacterial consortium. Our findings suggest that the two symbiotic organs within E. scolopes originated by different evolutionary mechanisms. Transcripts expressed in these microbe-associated tissues displayed their own unique signatures in both coding sequences and the surrounding regulatory regions. Compared with other tissues, the light organ showed an abundance of genes associated with immunity and mediating light, whereas the ANG was enriched in orphan genes known only from E. scolopes. Together, these analyses provide evidence for different patterns of genomic evolution of symbiotic organs within a single host.