Cerebellar Control of Reach Kinematics for Endpoint Precision
Cerebellar Control of Reach Kinematics for Endpoint Precision
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DOI：
10.1016/j.neuron.2019.05.007
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发表时间：
2019-07-17
期刊：
影响因子：
16.2
通讯作者：
Person, Abigail L.
中科院分区：
文献类型：
--
作者：
Becker, Matthew, I;Person, Abigail L.
人们普遍认为，小脑可以赋予熟练的动作以速度、流畅度和精确度，比如伸手。这些功能是如何由小脑的最终输出阶段--小脑核--执行的，目前尚不清楚。在这里，我们确定了小脑输出和小鼠伸展运动学之间的因果关系，并展示了这种关系如何被内源性地利用来提高伸展精度。前间隔核(INTA)的活动非常好地排列到终点，随着肢体减速的大小而变化。在REACH上触发的INTA活动的闭环光遗传调制支持这一活动在实时控制REACH速度中的因果作用。将内源性神经可变性与运动学可变性联系起来，我们发现INTA终点活动相对于初始到达速度的变化是适应性的，支持终点精度。综上所述，这些结果为理解中间小脑在精确熟练运动中的生理学和病理生理学提供了一个框架。
The cerebellum is well appreciated to impart speed, smoothness, and precision to skilled movements such as reaching. How these functions are executed by the final output stage of the cerebellum, the cerebellar nuclei, remains unknown. Here, we identify a causal relationship between cerebellar output and mouse reach kinematics and show how that relationship is leveraged endogenously to enhance reach precision. Activity in the anterior interposed nucleus (IntA) was remarkably well aligned to reach endpoint, scaling with the magnitude of limb deceleration. Closed-loop optogenetic modulation of IntA activity, triggered on reach, supported a causal role for this activity in controlling reach velocity in real time. Relating endogenous neural variability to kinematic variability, we found that IntA endpoint activity is adaptively engaged relative to variations in initial reach velocity, supporting endpoint precision. Taken together, these results provide a framework for understanding the physiology and pathophysiology of the intermediate cerebellum during precise skilled movements.