Interspecies Recombination Occurs Frequently in Quinolone Resistance-Determining Regions of Clinical Isolates of Streptococcus pyogenes
Interspecies Recombination Occurs Frequently in Quinolone Resistance-Determining Regions of Clinical Isolates of Streptococcus pyogenes
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DOI：
10.1128/aac.00518-08
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发表时间：
2008-11-01
影响因子：
4.9
通讯作者：
Pletz, Mathias W. R.
中科院分区：
文献类型：
--
作者：
Duesberg, Christoph B.;Malhotra-Kumar, Surbhi;Pletz, Mathias W. R.
化脓性链球菌对氟喹诺酮类药物耐药性的报道仅是传闻，但比利时最近的一项监测研究发现，不敏感率为 5.4%。通过对这些分离株的分析，我们发现 parC 喹诺酮耐药决定区内的种间水平基因转移是一种常见现象，可能导致氟喹诺酮耐药。
Fluoroquinolone resistance in Streptococcus pyogenes has been reported only anecdotally, but a recent Belgian surveillance study found a rate of nonsusceptibility of 5.4%. From an analysis of these isolates, we show that interspecies horizontal gene transfer within the parC quinolone resistance-determining region is a frequent phenomenon that might contribute to fluoroquinolone resistance.