Dietary patterns and adenocarcinoma of the esophagus and distal stomach
Dietary patterns and adenocarcinoma of the esophagus and distal stomach
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DOI：
10.1093/ajcn/75.1.137
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发表时间：
2002-01-01
影响因子：
7.1
通讯作者：
Tucker, KL
中科院分区：
文献类型：
--
作者：
Chen, HL;Ward, MH;Tucker, KL
背景：饮食模式分析是研究饮食与疾病关系的一种独特方法。目的：我们的目的是描述内布拉斯加州东部人群的饮食模式，并调查这些饮食模式与食道和远端胃腺癌风险之间的关系。设计：我们招募了124名食管腺癌患者。在一项基于人群的病例对照研究中，124名远端胃腺癌患者和449名对照患者。结果：利用聚类分析确定了六种饮食模式。第一种饮食模式代表了健康的食物选择，与其他饮食模式相比，水果、蔬菜和谷物产品对能量的贡献更高，红肉、加工肉类和肉汁对能量的贡献更低。相比之下，第二种饮食模式是肉类多，水果和谷物少。另外4种饮食模式的特点是能量来源集中：分别是咸零食、甜点、牛奶和白面包。不同饮食模式对远端胃腺癌的总体癌症风险差异的检验是显著的（P=0.04），但对食管腺癌没有显著差异。食道腺癌的风险与乳制品、鱼类、所有蔬菜、柑橘类水果和果汁以及黑面包的摄入量呈负相关，与肉汁的摄入量呈正相关。患远端胃腺癌的风险与红肉摄入量呈正相关。结论：我们的研究表明，多吃水果和蔬菜可能会降低患食管腺癌的风险，而多吃肉类可能会增加患远端胃腺癌的风险。
Background: Dietary pattern analysis is a unique approach to studying relations between diet and disease.Objective: Our objective was to describe the dietary patterns of an eastern Nebraska population and investigate the associations between those dietary patterns and risks of adenocarcinoma of the esophagus and distal stomach.Design: We recruited 124 subjects with esophageal adenocarcinoma. 124 subjects with distal stomach adenocarcinoma, and 449 control subjects in a population-based, case-control study.Results: Six dietary patterns were identified with the use of cluster analysis. The first dietary pattern represented healthy food choices and had higher energy contributions from fruit and vegetables and grain products and lower energy contributions from red meats, processed meats, and gravy than did the other dietary patterns. In contrast, a second dietary pattern was high in meats and low in fruit and cereals. The other 4 dietary patterns were each characterized by a concentrated energy source: salty snacks, desserts, milk, and white bread, respectively. The test of overall difference in cancer risk across dietary patterns was significant for distal stomach adenocarcinoma (P=0.04) but not for esophageal adenocarcinoma. Risk of esophageal adenocarcinoma was inversely associated with intakes of dairy products, fish, all vegetables, citrus fruit and juices, and dark bread and was positively associated with gravy intake. Risk of distal stomach adenocarcinoma was positively associated with red meat intake.Conclusions: Our study suggests that a diet high in fruit and vegetables may decrease the risk of esophageal adenocarcinoma and that a diet high in meats may increase the risk of distal stomach adenocarcinoma.