Effect of cholecystokinin, gastrin, secretin and GIP on sham feeding in the rat
Effect of cholecystokinin, gastrin, secretin and GIP on sham feeding in the rat
复制标题
缩胆囊素、胃泌素、促胰液素和GIP对大鼠假饲的影响
DOI：
10.1016/0031-9384(79)90298-1
复制
发表时间：
1979
影响因子：
2.9
通讯作者：
Gerard P. Smith
中科院分区：
文献类型：
--
作者：
D. Lorenz;G. Kreielsheimer;Gerard P. Smith
比较了不纯胆囊收缩素（CCK）及其合成肽（CCK-8）在假喂养大鼠体内的饱腹效力。假性摄入的抑制率和静息行为的发生率（餐后饱腹感的行为标志）是不纯CCK和CCK-8腹腔剂量的函数。当比较产生50%假喂养抑制所需的剂量时，不纯CCK的效力约为CCK-8的5倍。CCK-8在缓慢静脉输注时的饱腹感效力约为腹腔注射后的两倍。这表明饱腹感效应不依赖于静脉注射或腹腔注射后可能出现的短暂的高循环水平。在相同的试验条件下，其他3种肠道激素胃泌素、分泌素和胃抑制多肽对饱腹感的影响不显著。这些激素产生饱腹感的失败证明了CCK饱腹感效应的相对特异性。这些结果与肠道CCK至少部分介导食物在小肠中的餐后饱腹效应的假设一致。
The satiating potency of impure cholecystokinin (CCK) and of its synthetic octapeptide (CCK-8) were compared in sham feeding rats. The precent inhibition of sham intake and the incidence of resting behavior, a behavioral marker of postprandial satiety, were a function of the intraperitoneal dose of impure CCK and CCK-8. When the doses required to produce 50% inhibition of sham feeding were compared, impure CCK was about 5 times as potent as CCK-8. CCK-8 was about twice as potent for satiety during slow intravenous infusions than after intraperitoneal injections. This demonstrates that the satiety effect is not dependent on transient high, circulating levels that can occur after intravenous or intraperitoneal injections. Under the same test conditions, three other gut hormones, gastrin, secretin and gastric inhibitory polypeptide, had no significant satiety effect. The failure of these hormones to produce satiety demonstrates the relative specificity of the CCK satiety effect. These results are consistent with the hypothesis that intestinal CCK mediates at least part of the postprandial satiety effect of food in the small intestine.