Nuclear pores in genome architecture and enhancer function.
Nuclear pores in genome architecture and enhancer function.
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DOI：
10.1016/j.ceb.2019.04.001
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发表时间：
2019-06
影响因子：
7.5
通讯作者：
Pau Pascual-Garcia;M. Capelson
中科院分区：
文献类型：
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作者：
Pau Pascual-Garcia;M. Capelson
核基因组结构依赖于基因组和各种核支架之间的相互作用。一种这样的核支架是核孔复合物（NPC），其除了其核转运功能之外，还可以与下面的染色质相互作用。特别是，最近报道NPC与后生动物基因组中的许多增强子和超增强子相关，并且选择NPC组分已显示出促进特定基因组环的形成。在这里，我们提供了一个简短的概述，目前的模型增强子功能，并讨论最近的证据表明，NPC绑定增强子，并有助于拓扑基因组组织。我们还研究了基因和增强子如何靶向NPC可能有助于组织特异性基因组结构和表达程序的可能模型，包括NPC可能促进转录区室相分离的可能性。
Nuclear genome architecture relies on interactions between the genome and various nuclear scaffolds. One such a nuclear scaffold is the nuclear pore complex (NPC), which in addition to its nuclear transport function, can interact with underlying chromatin. In particular, NPCs have been recently reported to associate with a number of enhancers and superenhancers in metazoan genomes, and select NPC components have been shown to promote the formation of specific genomic loops. Here, we provide a brief overview of current models of enhancer function, and discuss recent evidence that NPCs bind enhancers and contribute to topological genome organization. We also examine possible models of how gene and enhancer targeting to NPCs may contribute to tissue-specific genome architecture and expression programs, including the possibility that NPCs may promote phase separation of transcriptional compartments.