Influence of chemotherapy on FDG uptake by human cancer xenografts in nude mice.
Influence of chemotherapy on FDG uptake by human cancer xenografts in nude mice.
复制标题
化疗对人癌裸鼠异种移植物摄取 FDG 的影响。
DOI：
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复制
发表时间：
1997
影响因子：
9.3
通讯作者：
R. Kanamaru
中科院分区：
文献类型：
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作者：
T. Yoshioka;H. Takahashi;H. Oikawa;S. Maeda;T. Ido;T. Akaizawa;H. Fukuda;R. Kanamaru
未标记
本研究使用人癌异种移植物（低分化人胃癌）体内模型，评价了PET与18 F-2-脱氧-2-氟-D-葡萄糖（18 F-FDG）用于监测化疗效果。
方法
在给药丝裂霉素（MMC）、顺铂（CDDP）和阿霉素（ADR）后，测量荷瘤裸鼠的18F-FDG摄取和肿瘤大小，并与非治疗组的18F-FDG摄取和肿瘤大小进行比较。还评估了摄取与尺寸之间的相关性。
结果
化疗后，MMC给药组的肿瘤体积缩小幅度最大，其次是CDDP组，ADR组与对照组相比没有缩小。化疗后，MMC组和CDDP组的氟-18-FDG肿瘤摄取也依次降低，但ADR病例中没有。使用MMC和CDDP，在第8天或第11天体积减小变得显著，而18F-FDG肿瘤摄取在第3天或第7天已经减少。
结论
氟-18-FDG摄取的减少与抗癌药物的疗效平行，并与随后的形态学变化相关。我们的结论是，18F-FDG PET肿瘤图像确实是有用的监测癌症化疗的效果。
UNLABELLED
This study evaluated the use of PET with 18F-2-deoxy-2-fluoro-D-glucose (18F-FDG) for monitoring chemotherapy effects, using a human cancer xenograft (poorly differentiated human gastric cancer) in vivo model.
METHODS
Tumor 18F-FDG uptakes and sizes were measured after administrating mitomycin (MMC), cisplatin (CDDP) and adriamycin (ADR) to xenograft-bearing nude mice and compared with 18F-FDG tumor uptake and tumor size in a non-therapy group. The correlation between the uptake and size was also assessed.
RESULTS
The largest reduction in tumor size after chemotherapy occurred in the MMC administered group, followed by the CDDP case, with no reduction in the ADR group as compared to the controls. Fluorine-18-FDG tumor uptake after chemotherapy was also decreased in the MMC and CDDP groups, in that order, but not in the ADR case. With MMC and CDDP, size reduction became significant on Days 8 or 11, whereas 18F-FDG tumor uptake had already been decreased on Days 3 or 7.
CONCLUSION
Fluorine-18-FDG uptake decreases in parallel to the efficacy of anticancer agents and correlates with subsequent morphologic changes. We conclude that 18F-FDG PET tumor images are indeed useful for monitoring the effects of cancer chemotherapy.
影响因子：
45.3
作者：
WAHL, RL;ZASADNY, K;CODY, R
通讯作者：
CODY, R
体外评估 2-氟-2-脱氧-D-葡萄糖、L-甲硫氨酸和胸苷作为监测人腺癌细胞系对放射治疗的早期反应的药物。
DOI：
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发表时间：
1993
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Higashi,K;Clavo,AC;Wahl,RL
通讯作者：
Wahl,RL
从 18F 标记的乙酰次氟酸合成 2-脱氧-2-[18F]氟-d-葡萄糖的新改进方法。
DOI：
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发表时间：
1982
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Shiue,CY;Salvadori,PA;Wolf,AP;Fowler,JS;MacGregor,RR
通讯作者：
MacGregor,RR