Multisite phosphorylation provides sophisticated regulation of transcription factors
Multisite phosphorylation provides sophisticated regulation of transcription factors
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DOI：
10.1016/s0968-0004(02)02207-7
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发表时间：
2002-12-01
影响因子：
13.8
通讯作者：
Sistonen, L
中科院分区：
文献类型：
--
作者：
Holmberg, CI;Tran, SEF;Sistonen, L
可逆磷酸化是一种普遍存在的机制，通过这种机制，真核转录因子的活性响应于细胞环境的变化而被快速调节。积累的证据已经将磷酸化的概念扩展到一个过程，该过程提供对因子的反式激活潜力的动态和精确调节，而不是静态的开/关开关。在转录因子如热休克因子1（HSF 1）、p53和活化T细胞核因子（NFAT）的情况下，多位点磷酸化使得在单个因子内起作用的几种作用成为信号整合的关键。对这些转录因子的研究说明了在解决多位点磷酸化转录调控的动态性质方面的最新进展。
Reversible phosphorylation is a prevalent mechanism by which the activity of eukaryotic transcription factors is regulated rapidly in response to changes in the cellular environment. Accumulated evidence has expanded the concept of phosphorylation to a process that provides dynamic and precise tuning of the transactivating potential of a factor, rather than being a static on/off switch. In the case of transcription factors such as heat shock factor 1 (HSF1), p53 and nuclear factor of activated T cells (NFAT), multisite phosphorylation enables several effects to operate within a single factor, thereby functioning as a key to signal integration. Studies on these transcription factors illustrate recent progress in solving the dynamic nature of transcriptional regulation by multisite phosphorylation.