Validation of the Knee Injury and Osteoarthritis Outcome Score (KOOS) for the treatment of focal cartilage lesions
Validation of the Knee Injury and Osteoarthritis Outcome Score (KOOS) for the treatment of focal cartilage lesions
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DOI：
10.1016/j.joca.2009.04.019
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发表时间：
2009-11-01
影响因子：
7
通讯作者：
Saris, D. B. F.
中科院分区：
文献类型：
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作者：
Bekkers, J. E. J.;de Windt, Th. S.;Saris, D. B. F.
目标：为了验证膝关节损伤和骨关节炎结果评分（KOCS）治疗局灶性软骨lesions.Methods：共40例（平均年龄35 +/- 12岁，）治疗局灶性软骨病变的膝盖被列入本研究。收集重测数据，中间间隔2天。要求患者完成荷兰KOOS和补充问卷[简表-36（SF-36）、Lysholm、EuroQol-5D（EQ-5D）]，以评价KOOS在内部一致性方面的临床特征（Cronbach's alpha），信度[类内相关（ICC）和Bland和Altman图]，结构效度结果：KOOS各子领域和总分的Cronbach’s α值在0.74 ~ 0.96之间。KOOS的整体ICC为0.97，而分量表的范围为0.87至0.95。Bland和Altman图显示两次评估之间的时间个体差异较小。KOOS分量表与SF-36、Lysholm和EQ-5D代表性分量表之间的斯皮尔曼等级相关性为高至中度，范围为0.43至0.70。我们没有观察到地板效应，而观察到的最大天花板效应为10.3%。反应度为中到大，效应量范围为0.70 ~ 1.32，标准化反应均值为0.61 ~ 0.87。结论：KOOS量表用于评价局灶性软骨病变治疗后的临床状况具有良好的信度和效度。本研究为KOOS在软骨修复的临床研究中的应用奠定了基础。(C)2009年国际骨关节炎研究学会。由爱思唯尔有限公司出版。保留所有权利。
objective: To validate the Knee Injury and Osteoarthritis outcome Score (KOCS) for the treatment of focal cartilage lesions.Methods: A total of 40 patients (mean age 35 +/- 12 years,) treated for a focal cartilage lesion in the knee were included in this study. Testretest data were collected with an intermediate period of 2 days. Patients were asked to complete the Dutch KOOS and complementary questionnaires [short form-36 (SF-36), Lysholm, EuroQol-5D (EQ-5D)] to evaluate the clinimetric properties of the KOOS in terms of internal consistency (Cronbach's alpha), reliability [intra-class-correlation (ICC) and Bland and Altman plots], construct validity (Spearman's rank correlation), floor and ceiling effects and responsiveness.Results: The Cronbach's alpha of the KOOS subdomains and total score ranged from 0.74 to 0.96. The overall ICC of the KOOS was 0.97 while the subscales ranged from 0.87 to 0.95. The Bland and Altman plots showed a small individual variance between the two assessments in time. Spearman's rank correlations between the subscales of the KOOS and representative subscales of the SF-36, Lysholm and EQ-5D were high to moderate ranging from 0.43 to 0.70. We observed no floor effect while the largest observed ceiling effect was 10.3%. The responsiveness was moderate to large with the effect size ranging from 0.70 to 1.32 and the standardized response mean 0.61 to 0.87.Conclusion: This study illustrates the validity and reliability of the KOOS in measuring the clinical condition of patients after treatment of focal cartilage lesions. This study provides a basis for the use of the KOOS for future clinical research in cartilage repair. (C) 2009 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.